中西医结合治疗骨髓增生异常综合征

本文报道50例骨髓增生异常综合征的中西医结合治疗。其中难治性贫血及环形铁粒幼细胞性难治性贫血以调节造血、免疫功能的药物治疗;难治性贫血伴有原始细胞增多、慢性粒单核细胞白血病或转变中的原始细胞增多的难治性贫血给予小剂量化疗,两组均加服中药。两组有效率分别为47.83%及62.96%,总有效率为56%。6例用全反式维甲酸诱导分化治疗,2例有效。11例转为白血病之后用小剂量或联合化疗配合中药治疗,缓解率54.55%,缓解后存活期9～27个月。小剂量化疗具有细胞毒及诱导分化作用。中药可改善症状和体征,利于血像和骨髓像的恢复,防止感染及提高机体免疫力。

Treatment of Myelodysplastic Syndrome by Combined TCM-WM Therapy

50 cases were treated with Myelodysplastic Syndrome (MDS) by combined TCM-WM therapy.They were classified into RA 17 cases, RAS 6, RAEB 19, CMML 1 and RAEBT 7. The patients weredivided into two groups, one with RA and RAS receiving treatment of hemopoietic and immunedrugs plus Chinese medicinal herbs, the other with RAEB, CMML and RAEBT receiving treatmentof LD Ara-c and LD Hom chemotherapy plus medicinal herbs. The effective rates were 47.83% and62.96% respectively, the total effective rate being 56%. 6 cases (RAEB 4, RA 1, RAS 1) were treatedwith all-trans retinoic acid used as an inducer of differentiation, 2 of them were effective. 11 patientswith MDS who had transformed into acute leukemia were treated by LD Ara-c and combined TCM-WM chemotherapy, the remission rate was 54.55% and the survival period was 9-27 months afterremission. In some cases low dose chemotherapy resulted in hemocytopenia, bone marrow inhibition,infection, mild nausea and anorexia.