| 水溶性壳聚糖抗肿瘤作用的实验研究 |
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| 引用本文： | 王芳宇,何淑雅,李邦良,费树荣. 水溶性壳聚糖抗肿瘤作用的实验研究[J]. 中国生化药物杂志, 2001, 22(1): 21-22 |
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| 作者姓名： | 王芳宇 何淑雅 李邦良 费树荣 |
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| 作者单位： | 衡阳医学院, |
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| 摘 要： | 目的研究水溶性壳聚糖对抗肿瘤活性因子和NK细胞活性的影响。方法分别用不同浓度水溶性壳聚糖腹腔注射荷瘤小鼠 ,然后测定巨噬细胞一氧化氮 (NO)、肿瘤坏死因子 (TNF)的生成 ,以及脾细胞γ 干扰素(IFN γ)和NK细胞活性。结果水溶性壳聚糖有显著地促进荷瘤小鼠NO、TNF、IFN γ的生成 ,提高NK细胞活性。与对照相比P <0 .0 1。结论水溶性壳聚糖能提高荷瘤小鼠的免疫功能。
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| 关 键 词： | 水溶性壳聚糖 一氧化氮 肿瘤坏死因子 γ-干扰素 NK细胞活性 |
| 文章编号： | 1005-1678(2001)01-0021-02 |
| 修稿时间： | 2000-05-18 |
Effect of soluble chitosanon antitumor in rats |
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| WANG Fang-yu,HE Shu-ya,LI Bang-liang,FEI Shu-rong. Effect of soluble chitosanon antitumor in rats[J]. Chinese Journal of Biochemical Pharmaceutics, 2001, 22(1): 21-22 |
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| Authors: | WANG Fang-yu HE Shu-ya LI Bang-liang FEI Shu-rong |
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| Abstract: | Purpose The aim is to study the effects of solubl e chit osan on antitumor factors and NK cell activity in rats.Methods The level of NO、TNF produced by peritoneal macrophages,IFN-γ production and NK ce ll activity of spleen was detected,after different concentrations of chitosan we re injected into the sarcoma 180 rats peritoneally.Results Th e cont ents of NO、TNF、IFN-γ and NK cell activity in sacroma 180 rats were significa ntly higher in the chitosan groups than those in the control group (P＜0.01) .Conclusion Chitosan could impove the immune function in rats . |
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| Keywords: | Soluble chitosan Nitric oxide Tumor necrosis factor Interferon γ Natural killer cell |
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