Synthesis and pharmacology of 3-aryl-5,6-dihydro-6-oxo-1(4H)-pyridazineacetic acid derivatives. |
| |
| Authors: | J M Kane E W Huber F P Miller J H Kehne |
| |
| Institution: | Marion Merrell Dow Research Institute, Cincinnati, Ohio. |
| |
| Abstract: | The title compounds were prepared by alkylation of 6-aryl-4,5-dihydro-3(2H)-pyridazinones with esters of alpha-bromoacetic acid. Hydrolysis of these esters afforded the corresponding carboxylic acids which were coupled with various amines yielding 6-oxo-1(4H)-pyridazineacetamides. A number of these derivatives showed weak anticonvulsant and weak analgesic activities, while nearly all displayed a sedative profile. |
| |
| Keywords: | |
|
|
