| 苦参碱缓释包衣微丸的研制 |
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| 引用本文： | 宋磊,张亚琼,郭圣荣,殷明.苦参碱缓释包衣微丸的研制[J].中国药学杂志,2005,40(16):1238-1240. |
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| 作者姓名： | 宋磊 张亚琼 郭圣荣 殷明 |
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| 作者单位： | 上海交通大学药学院,上海,200030 |
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| 摘 要： | 目的采用乙基纤维素水分散体(Surelease)制备苦参碱缓释微丸。方法采用溶液上药法(流化床底喷装置)制备苦参碱微丸,并进行微丸质量评价及粉体学性质研究;用Surelease作为包衣材料、微型流化床进行包衣,对微丸体外释放进行评价并考察热处理对微丸释放的影响。结果制备的微丸质量良好,苦参碱缓释微丸需要热处理,适宜的热处理温度为60℃,热处理时间为12 h,体外释放曲线符合一级动力学方程。结论制备的苦参碱缓释微丸具有明显缓释作用。
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| 关 键 词： | 苦参碱 缓释微丸 乙基纤维素水分散体 流化床 |
| 文章编号： | 1001-2494（2005）16-1238-04 |
| 收稿时间： | 2004-11-22 |
| 修稿时间： | 2004-11-22 |
Preparation of sustained-release coated pellets of matrine |
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| SONG Lei,ZHANG Ya-qiong,GUO Sheng-Rong,YIN Ming.Preparation of sustained-release coated pellets of matrine[J].Chinese Pharmaceutical Journal,2005,40(16):1238-1240. |
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| Authors: | SONG Lei ZHANG Ya-qiong GUO Sheng-Rong YIN Ming |
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| Institution: | School of Pharmacy， Shanghai Jiao Tong University， Shanghai 200030， China |
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| Abstract: | OBJECTIVE To study the preparation of sustained-release coated pellets of matrine. METHODS The drug-containing pel-Ids were prepared in the fluid-bed by solution layering and then coated in subminiature fluid-bed with Surelease. The quality and micromeritics of pellets were evaluated. The release characteristics and the effects of thermal treatment on release profiles were studied.RESULTS The drug-containing pellets were prepared well and the coated pellets needed thermal treatment at 60℃ for 12 h. The curve of cumulative drug release was accorded with the first grade equation. CONCLUSION The pellets show an obviously sustained-release effect. |
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| Keywords: | matrine sustained-release pellets aqueous ethyl cellulose dispersion spray fluid-bed |
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