MEDULLARY CARCINOMA OF THE THYROID WITH ECTOPIC ACTH SYNDROME |
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| Authors: | Kenichi Kakudo Akira Miyauchi Toshio Ogihara Shin-ichiro Takai Hajime Kitamura † Yuichi Kumahara Akira Kawaoi ‡ |
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| Institution: | *Department of Pathology (Hospital), Hyogo College of Medicine, Nishinomiya;**Department of Surgery, Osaka University Medical School, Osaka;*** Department of Medicine and Geriatrics, Osaka University Medical School, Osaka;?Department of Pathology, Osaka University Medical School, Osaka;?Department of Pathology, Nihon University Medical School, Tokyo |
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| Abstract: | An autopsied patient with medullary carcinoma of the thyroid and ectopic ACTH syndrome is reported. A microadenoma of pancreatic islet coexisted in this case, which is assumed to be of D cell origin. Immunohistochemical study revealed decreased number of pituitary ACTH cells. Some of them showed Crooke's degeneration. Hormone assay study of tumor tissue and plasma disclosed abnormal ACTH, β-MSH as well as calcitonin. Somatostatin and Substance P were also demonstrated in tissue. Histologically the tumor showed solid alveolar pattern with a minor part consisting of small cell variant and this histologic variation is discussed. |
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