精浆前列腺特异性抗原检测的临床意义

目的检测清浆PSA与F-PSA,并探讨其在临床上的应作价值。方法 用化学发光标记免疫技术稀释检测法,检测30例健康男性组,30例BPH患者组和15例PCa患者组精浆PSA与F-PSA浓度水平,用回收试验和重复性试验和重复性试验来验证检测的正确性。并采用计算机SAS软件包(version 8.2)进行统计分析。结果(1)健康男性组精浆中PSA浓度范围为302800～1340000ng/ml,(587240±234394)ng/ml。F-PSA浓度范围为212800～778000ng/ml,(419720±148637)ng/ml。比血清PSA及F-PSA高出几十万倍。(2)BPH组精浆PSA与F-PSA浓度略高于正常对照组,但差异无统计学意义。(3)Pac组精浆PSA及F-PSA浓度低于正常对照组及BPH组,差异有高度显著性,有统计学意义。(4)前列腺癌患者精浆PSA与肿瘤分期Spearman和Kendall等级相关分析结果显示前列腺癌患者精浆PSA含量与肿瘤分期间相关不显著。结论 检测精浆PSA与F-PSA对前列腺癌与良性前列腺增生的鉴别有一定的临床应用价值。

Clinical significance of detection prostate specific antigen in seminal plasma

Objective To detect PSA in seminal plasma and analyze the clinical significance of the detection PSA in seminal plasma. Methods Collecting 30 healthy men, 30 BPH patients and 15 Pca patients, detect the concentration of F-PSA and PSA in seminal plasma and discuss the clinical significance. All information is made statistice of with computer SAS software package (version 8. 2). Results The concentration of PSA and F - PSA in Pca seminal plasma is inferior to BPH and healthy men, P < 0.0001. Conclusions Through studying result, detection the concentration of PSA in seminal plasma can help to distinguish early prostate cancer and benign prostatic hyperplasia, has clinical application val-ue.