| P170蛋白和抑凋亡基因bcl-2在胰腺癌组织中的表达及临床意义 |
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| 引用本文： | 王毅,顾建华,郭仁德. P170蛋白和抑凋亡基因bcl-2在胰腺癌组织中的表达及临床意义[J]. 河北医药, 2011, 33(6): 805-807. DOI: 10.3969/j.issn.1002-7386.2011.06.001 |
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| 作者姓名： | 王毅 顾建华 郭仁德 |
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| 作者单位： | 天津市第一中心医院普通外科,300192 |
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| 基金项目： | 天津市卫生局科研基金资助项目 |
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| 摘 要： | 目的 研究胰腺癌组织中P170和抑凋亡基因bcl-2的表达及其临床意义.方法 对81例胰腺癌标本应用免疫组化方法测定标本中凋亡抑制基因bcl-2的基因蛋白产物以及P170蛋白表达.结果 胰腺癌组织中P170、bcl-2的阳性表达率分别为67.9%和72.8%.bcl-2表达与肿瘤TNM分期有关(P<0.05),与肿瘤直...
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| 关 键 词： | 胰腺肿瘤 免疫组织化学 抗药性,肿瘤 P170 bcl-2基因 |
The expression and clinical significance of P170 protein and Bcl-2 gene in pancreatic carcinoma |
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| WANG Yi,GU Jianhua,GUO Rende. The expression and clinical significance of P170 protein and Bcl-2 gene in pancreatic carcinoma[J]. Hebei Medical Journal, 2011, 33(6): 805-807. DOI: 10.3969/j.issn.1002-7386.2011.06.001 |
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| Authors: | WANG Yi GU Jianhua GUO Rende |
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| Affiliation: | WANG Yi,GU Jianhua,GUO Rende.Department of Surgery,The First Central Hospital of Tianjin City,Tianjin 300192,China |
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| Abstract: | Objective To investigate the expression of Pl70 and bcl-2 gene in patients with pancreatic carcinoma and explore its clinical value.Methods The protein expressions of P170 and bcl-2 gene were detected by immunohistochemistry in 81 parafin-embedded specimens from patients with pancreatic carcinoma.Results The positive rates of P170 and bcl-2 protein in pancreatic carcinoma were 67.9% and 72.8% respectively.Before operation the positive expression rates of P170 and bcl-2 gene in chemotherapy group were signif... |
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| Keywords: | P170 |
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