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| P53和Ki-67及Survivin在甲状腺乳头状癌中的表达研究 | |
| 引用本文： | 陈洪杰,孟予城,孙革,杨树森,张占杰,刘艳荣,刘立衡,李小平.P53和Ki-67及Survivin在甲状腺乳头状癌中的表达研究[J].河北医药,2011,33(6):823-825. |
| 作者姓名： | 陈洪杰 孟予城 孙革 杨树森 张占杰 刘艳荣 刘立衡 李小平 |
| 作者单位： | 1. 河北省廊坊市人民医院普外科,065000 2. 河北省廊坊市中医医院检验科 3. 河北省廊坊市人民医院病理科,065000 |
| 摘 要： | 目的探讨P53、Ki-67和survivin在甲状腺乳头状癌组织中的表达及相互关系。方法应用免疫组织化学（S-P）检测35例甲状腺乳头状癌,28例甲状腺腺癌组织中P53、Ki-67和survivin的表达情况。结果 P53、Ki-67和survivin在甲状腺乳头状癌组织中的表达阳性率分别是85.71%、65.71%和74.2%,与甲状腺腺瘤相比较差异有统计学意义（P〈0.01）。P53、Ki-67的表达与survivin的表达无相关关系（rs分别为0.05177和0.02457,P〉0.05）。P53、Ki-67和survivin在甲状腺乳头状癌组织中的表达与性别、年龄、结节数量、肿瘤大小无关（P〉0.05）。结论 P53、Ki-67和survivin在甲状腺乳头状癌中的表达增高,P53、Ki-67与survivin的表达无相关关系。 |
| 关 键 词： | 甲状腺肿瘤 癌 乳头状 基因 P53 Ki-67 Survivin |
Expression of P53,ki67 and Survivin in papillary thyroid carcinoma |
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| Institution: | CHEN Hongjie,MENG Yucheng,SUN Ge,et al.Department of Surgery,People＇s Hospital of Langfang city,Hebei,Langfang 065000,China |
| Abstract: | Objective To investigate the expression of P53,Ki67 and Survivin and to analyze their relationship in papillary thyroid carcinoma.Methods Immunohistochemical method（SP） was used to detect expression of P53,Ki67,Survivin in 35 cases of papillary thyroid carcinoma and 28 cases of thyroid adenoma.Results The positive expression rates of P53,Ki67,Survivin were 85.71%,65.71%,74.2% respectively in papillary thyroid carcinoma,which were significantly higher than those in thyroid adenoma（P0.01）.The expressions of P53,ki67 were not related with that of Survivin（P0.05）.The expression of P53,Ki67,Survivin were not correlated with patinets＇sex,age,nodule number,tumor size in papillary thyroid carcinoma（P0.05）.Conclusion The expressions of P53,ki67,Survivin are increased in papillary thyroid carcinoma.However the expression of P53,Ki67 is not correlated with that of Survivin. |
| Keywords: | Ki-67 Survivin |
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