| 齐拉西酮与氯氮平治疗精神分裂症对照研究 |
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| 引用本文： | 滕林,林勇,查显友. 齐拉西酮与氯氮平治疗精神分裂症对照研究[J]. 安徽医学, 2011, 32(3): 280-282. DOI: 10.3969/j.issn.1000-0399.2011.03.010 |
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| 作者姓名： | 滕林 林勇 查显友 |
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| 作者单位： | 浙江省嘉兴市康慈医院精神科,嘉兴,314500;浙江省嘉兴市康慈医院精神科,嘉兴,314500;浙江省嘉兴市康慈医院精神科,嘉兴,314500 |
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| 摘 要： | 目的比较齐拉西酮与氯氮平治疗精神分裂症的临床疗效与安全性。方法将精神分裂症患者100例随机分为齐拉西酮组与氯氮平组。疗程12周。采用阳性与阴性症状量表（PANSS）及治疗中出现的症状量表（TESS）、健康状况问卷（SF-36）评定临床疗效、不良反应和生存质量。结果两组治疗后PANSS评分均显著下降,两组间比较差异无统计学意义,不良反应发生率齐拉西酮组显著低于氯氮平组。结论齐拉西酮治疗精神分裂症疗效与氯氮平相仿,锥体外系副反应发生率明显高于氯氮平组,但不良反应总体发生率相对较少,可以提高患者生活质量,是一种安全有效的抗精神病药。
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| 关 键 词： | 齐拉西酮 氯氮平 精神分裂症 |
Comparative study between ziprasidone and clozapine in treatment of schizophrenia |
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| Ten Lin,Lin Yong,Zha Xianyou. Comparative study between ziprasidone and clozapine in treatment of schizophrenia[J]. Anhui Medical Journal, 2011, 32(3): 280-282. DOI: 10.3969/j.issn.1000-0399.2011.03.010 |
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| Authors: | Ten Lin Lin Yong Zha Xianyou |
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| Affiliation: | Ten Lin,Lin Yong,Zha Xianyou Department of Psychiatry,Jiaxing Kangci Hospital,Jiaxing 314500,China |
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| Abstract: | Objective To compare the clinical efficacy and safety between ziprasidone and clozapine in the treatment of schizophrenia.Methods 100 patients with schizophrenia were randomly divided into ziprasidone group and clozapine group for a 12-week treatment.Positive and negative symptom scale(PANSS),treatment emergent symptom scale(TESS),and short from 36 health survey questionnaire(SF-36) were used to evaluate the efficacy and safety.Results The total scores of PANSS obviously decreased in both groups and there w... |
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| Keywords: | Ziprasidone Clozapine Schizophrenia |
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