| 纳洛酮对脑出血大鼠脑血肿周围FADD表达及脑水肿的影响 |
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| 引用本文： | 孙晓培,黄贺森,刘超,任向利,吕铭新.纳洛酮对脑出血大鼠脑血肿周围FADD表达及脑水肿的影响[J].河北医药,2011,33(6):810-812. |
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| 作者姓名： | 孙晓培 黄贺森 刘超 任向利 吕铭新 |
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| 作者单位： | 1. 河北省廊坊市第四人民医院神经内二科,056700
2. 河北省廊坊市第四人民医院,056700 |
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| 摘 要： | 目的研究大鼠脑出血不同时期Fas相关死亡域蛋白（FADD）表达和脑水肿及纳洛酮对其的影响,探讨纳洛酮脑保护机制。方法 126只SD雄性大鼠随机分为假手术组、脑出血组、纳洛酮治疗组,每组42只采用自体血脑内注射法建立脑出血动物模型,应用免疫组化方法检测脑出血后不同时间点血肿周边脑组中FADD表达情况,干湿比重法测脑水肿。结果出血后3hFADD和脑水肿升高,48～72h达到高峰,与脑出血组比较纳洛酮治疗组FADD和脑水肿表达显著减少（P〈0.01）。结论脑出血后血肿周围细胞FADD表达和脑水肿明显增多,纳洛酮可能通过抑制FADD的表达,减轻脑水肿,对脑出血后脑组织有保护作用。
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| 关 键 词： | 脑水肿 脑出血 Fas相关死亡域蛋白 纳洛酮 |
The experimental study of the effect of naloxone on the expression of FADD and brain edema in rats with intracerebral hemorrhage |
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| SUN Xiaopei,HUANG Hesen,LIU Chao,et al..The experimental study of the effect of naloxone on the expression of FADD and brain edema in rats with intracerebral hemorrhage[J].Hebei Medical Journal,2011,33(6):810-812. |
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| Authors: | SUN Xiaopei HUANG Hesen LIU Chao |
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| Institution: | SUN Xiaopei,HUANG Hesen,LIU Chao,et al.Department of Neurology,The Fourth Hospital of Langfang City,Hebei,Langfang 056700,China |
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| Abstract: | Objective To observe the protein expressions of Fas-associated with death domain protein(FADD) and brain edema in rats with intacerebral hemorrhage(ICH),and to investigate the effects of naloxone on them in order to reveal the action mechanism of neuroprotection of naloxone.Methods 126 male SD rats were randomly divided into three groups:sham-operation group,intracerebral hemorrhage group and naloxone treatment group.The model of ICH was established in rats by intracerebral injection of autogenous blood.The... |
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| Keywords: | brain edema intracerebral hemorrhage FADD naloxone |
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