THE LIVER PEPTIDES AFTER CHRONIC ADMINISTRATION OF ETHANOL IN RATS |
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Authors: | FARBISZEWSKI, R. GABRYEL, H. |
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Affiliation: | Department of Inorganic and Analytical Chemistry, Medical Academy PI 15230 Bialystok 8, Poland |
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Abstract: | The liver peptide fractions labelled with 3H-arginine afterchronic administration of ethanol to rats have been analysedby gel filtration chromatography and tlc. Specific 3H-arginineradioactivity in the liver peptide fraction calculated per µgof -amino nitrogen was significantly decreased by alcohol. Theamount of peptide spots obtained by tlc in the ethanol-treatedgroup was reduced in comparison with the control group. Thefindings suggest a change in the protein metabolism in hepaticdysfunction in rats receiving ethanol over a prolonged period. |
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