南宁市健康人群N末端B型利钠肽原水平的影响因素及正常参考范围的预测

目的：探讨南宁市城乡健康人群血浆N末端B型利钠肽原（ NT-proBNP）水平及影响因素，并预测其正常参考范围。方法南宁市城乡健康人群1087人，其中男性491人，女性596人，运用荧光免疫分析法检测血浆NT-proBNP。采取经验法估计NT-proBNP正常参考范围，分析影响南宁市城乡居民健康人群血浆NT-proBNP水平的因素。结果性别、年龄及体重指数是健康人群NT-proBNP水平的影响因素（P＜0．05）。年龄＜75岁男性的NT-proBNP水平明显低于女性（P＜0．05）。年龄≥75岁时男女间NT-proBNP水平比较，差异无统计学意义（P＞0．05）。男性＜45岁、45～＜55岁、55～＜65岁、65～＜75岁的正常NT-proBNP水平参考范围分别为7．7～86．6 ng／L、9．7～105．6 ng／L、11．7～127．2 ng／L、13．8～154．6 ng／L。女性＜45岁、45～＜55岁、55～＜65岁、65～＜75岁的正常NT-proBNP水平参考范围分别为9．5～108．5 ng／L、11．7～131．6 ng／L、14．3～159．6 ng／L、17．1～192．8 ng／L。结论影响南宁市健康人群NT-proBNP水平的主要因素是性别、年龄及体重指数，根据以上影响因素建立健康人群NT-proBNP水平的参考范围有重要意义。

Influencing factors and prediction of normal reference range of N-terminal pro-B-type natriuretic peptide in healthy population from Nanning

Objective To explore the level and its influencing factors of N-terminal pro-B-type natriuretic peptide(NT-proBNT) in healthy population from urban and rural areas in Nanning ,and to predict the normal reference range of NT-proBNT level .Methods A total of 1 087 healthy individuals in urban and rural areas of Nanning were selected , including 491 males and 596 females .The plasma NT-proBNP was detected by fluorescence immunoassay .The normal reference range of NT-proBNP level was estimated by empirical method,and the factors that affected the level of NT-proBNP in the healthy population of urban and rural residents in Nanning were analyzed.Results Gender,age and body mass index were the influencing factors of NT-proBNP level in healthy population (P<0.05). For the individuals aged less than 75 years,the NT-proBNP level of the male was significantly lower than that of the female (P<0.05). There was no significant difference in the NT-proBNP level between the male and female aged 75 years or older than 75 years(P>0.05). The normal reference ranges of NT-proBNP level in the males aged <45 years,from 45 to <55 years,from 55 to <65 years and from 65 to <75 years were (7.7-86.6)ng/L,(9.7-105.6)ng/L,(11.7-127.2)ng/L and (13.8-154.6)ng/L respectively.The normal reference ranges of NT-proBNP level in the females aged<45 years,from 45 to <55 years,from 55 to <65 years and from 65 to <75 years were (9.5-108.5)ng/L,(11.7-131.6)ng/L,(14.3-159.6)ng/L and (17.1-192.8)ng/L respectively.Conclusion The main factors affecting the NT-proBNP level of healthy population in Nanning are gender ,age and body mass index.These influencing factors are important for establishing the reference range of NT-proBNP level in healthy population .