人胎视网膜神经节细胞发育的光电镜观察及其临床意义

近年文献提出图形视网膜电图(P-ERG)的诱发来自节细胞;弱视儿童的 P-ERG 振幅下降,提示弱视的发病与节细胞的发育有关。本文在光镜和电镜下研究了51例胎儿视网膜神经节细胞的发育,为弱视病因的探讨提供形态学基础。结果表明:胚胎早期节细胞核大、胞浆少,核浆比例为5∶1,细胞器少。随胎龄增长核偏移、缩小,胞浆逐渐增多,细胞器增多。胚胎中期核浆比例为2∶1。胎儿8个月后核浆比例为1∶2,核明显缩小并偏向一极。细胞器极丰富,其结构与成人相同提示成熟。

Morphological studies on the development of human retinal ganglion cells and its clinical significance

In order to explore the mohpolo-ical pathogeny of amblyopia,the de-velopment of human retinal ganglioncells was observed in 51 fetal specim-ens by light and electron microscope.It was found that at the early stage,nucleus of ganglion cell was large,with a ratio of 5 to 1 to its plasma.The nucleus became deviated apartfrom the center and reduced insize,while the plasma and cell org-anelles increased gradually,andthe ratio between necleus and plasma decreased of 2 to 1 at the middle stage.At the end of the 8th month of ges-tation,the ratio was reduced to 1 to2 and the nucleus shifted to the pol-ar area,indicating a maturity of thestructures.