| ERCC1与恶性肿瘤化疗疗效及预后的最新进展 |
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| 引用本文： | 张树生,谷永红. ERCC1与恶性肿瘤化疗疗效及预后的最新进展[J]. 实用预防医学, 2010, 17(4): 817-819 |
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| 作者姓名： | 张树生 谷永红 |
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| 作者单位： | 1. 中南大学湘雅三医院,湖南,长沙,410013;长沙市第八医院
2. 中南大学湘雅三医院,湖南,长沙,410013 |
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| 摘 要： | 核苷酸切除修复交叉互补组1（ERCC1）是核苷酸切除修复途径的限速酶,ERCC表达与多种恶性肿瘤的化疗疗效及预后相关联,ERCC1单核苷酸多态性与肿瘤患者对化疗药物的敏感程度和预后有关,有助于预测化疗反应性。
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| 关 键 词： | ERCC1 化疗 预后 单核苷酸多态性 |
Research Progress About Chemotherapeutic Effect and Prognosis of Excision Repair Cross-complementing 1 on Malignancies |
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| ZHANG Shu-sheng,GU Yong-hong. Research Progress About Chemotherapeutic Effect and Prognosis of Excision Repair Cross-complementing 1 on Malignancies[J]. Practical Preventive Medicine, 2010, 17(4): 817-819 |
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| Authors: | ZHANG Shu-sheng GU Yong-hong |
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| Affiliation: | ZHANG Shu-sheng,GU Yong-hong (The Third Xiangya Hospital of Central South University,Changsha 410013,Hunan,China) |
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| Abstract: | Excision repair cross-complementing 1(ERCC1) is the rate-limiting enzyme in nucleotide excision repair pathway.The expression of ERCC1 was reported to be correlated with chemotherapy effect and prognosis of the patients who are treated with chemotherapy in several cancers.ERCC1 polymorphisms which influence the sensitivity to chemotherapy and the prognosis may be helpful in predicting the chemotherapy response. |
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| Keywords: | ERCC1 |
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