| 狭序唐松草中三类生物碱对血小板聚集的影响 |
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| 引用本文： | 田泽,高光耀,杨峻山,李玲玲,肖培根.狭序唐松草中三类生物碱对血小板聚集的影响[J].中草药,2000,31(11):839-841. |
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| 作者姓名： | 田泽 高光耀 杨峻山 李玲玲 肖培根 |
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| 作者单位： | 中国医学科学院,中国协和医科大学,药用植物研究所,北京,100094 |
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| 基金项目： | 国家自然科学基金!资助课题，编号第 395 70 0 85号 |
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| 摘 要： | 目的：研究狭序唐松草中三类生物碱ＢＢＩ、ＡＢＩ、ＡＰ的抗血小板聚集作用。方法：采用比浊法进行体外抗血小板聚集研究。结果：ＢＢＩ类和ＡＢＩ类能够抑制ＡＤＰ、Ｃｏｌｌ诱导的大鼠血小板聚集，ＡＰ类与正常对照相比则无显著差异。结论：ＢＢＩ类和ＡＢＩ类具有抗血小板聚集作用。且ＢＢＩ类作用强于ＡＢＩ类，ＡＰ类则几乎无作用。
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| 关 键 词： | 狭序唐松草 生物碱 血小板聚集 中医药治疗 |
| 收稿时间： | 2/4/2000 12:00:00 AM |
Effects of Three Kinds of Alkaloids in Thalictrum atriplex on Rat Platelet Aggregation |
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| Tian Ze,Gao Guangyao,Yang Junshan,Li Lingling and Xiao Peigen.Effects of Three Kinds of Alkaloids in Thalictrum atriplex on Rat Platelet Aggregation[J].Chinese Traditional and Herbal Drugs,2000,31(11):839-841. |
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| Authors: | Tian Ze Gao Guangyao Yang Junshan Li Lingling and Xiao Peigen |
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| Abstract: | Inhibition of platelet aggregation by aporphine (AP), bio benzyl isoquinoline (BBI) and aporphine benzyl isoquinoline (ABI) alkaloids in Thalictrum atriplex Finet et Gagnep in vitro was studied by turbidimetry Results of the study showed that both BBI and ABI alkaloids could inhibit ADP and collagen induced platelet aggregation, while the AP alkaloids was devoid of such action In conclusion, the alkaloids of BBI and ABI types have the effect of antiplatelet aggregation, with BBI showing the strongest activity, ABI the next and AP almost without any effect |
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| Keywords: | Thalictrum atriplex Finet et Gagnep alkaloids platelet aggregation |
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