血清胱抑素C在高血压早期肾损伤中的诊断价值

目的探讨血清胱抑素C（Cystain C）水平在原发性高血压早期肾损伤中的临床诊断价值。方法选择我院收治的高血压1～2级患者共78例作为观察组，同时选择79例健康体检者作为对照组，分别检测两组治疗前后Cystain C、24h尿清蛋白定量、血清肌酐（Scr）、内生肌酐清除率（Ccr）等。结果两组SBP、DBP、血清胱抑素C、24h尿清蛋白定量、内生肌酐清除率间差异有统计学意义（P〈0．01），血清肌酐间差异无统计学意义（P〉0．05）。观察组中Cystain C与24h尿清蛋白定量、血清肌酐、内生肌酐清除率有较好的相关性，并且血清胱抑素C与尿清蛋白定量的相关性优于Scr、Ccr的相关性，并与尿清蛋白定量、血清肌酐方向一致。结论血清Cystain C的浓度比Scr浓度更能够反映肾小球滤过功能的损害，是早期诊断肾小球滤过功能受损的敏感指标。

Application of Cystatin C to Diagnosis of Early Renal Impairment in Patients with Hypertension

Objective To evaluate the applicability of serum cystatin C to diagnosis of early renal impairment in patients with hypertension. Methods Subjects consisted of 41 normotensive controls and 78 unrelated Chinese essential hypertensive patients, the data of Serum Cystain C, 24h urine microprotein （mAlb）, serum cr and Cer were obtained by automated biochemical analyzer before and after the treatment. Results After the treatment, Scr had no significant statistical difference between the hypertension group and control group （P 〉0. 05）, while in terms of Cystain C, 24h mAlb, Ccr, significant differences were observed （P 〈 0. 01 ）. Conclusion Analysis of serum cystatin C would be more helpful to estimating the early renal impairment of patients with hypertension effectively than Scr.