益心康泰胶囊联合曲美他嗪治疗老年不稳定型心绞痛

目的：研究益心康泰胶囊联合曲美他嗪对老年不稳定型心绞痛患者的临床疗效。方法将66例老年不稳定型心绞痛患者随机分为对照组和益心康泰胶囊与曲美他嗪联合治疗组，每组33例。对照组只给予常规抗心绞痛药物治疗，联合治疗组在给予常规抗心绞痛药物治疗的同时，另给予益心康泰胶囊与曲美他嗪。疗程为1个月。观察治疗前后药物对患者心绞痛症状、心电图 ST-T、血小板聚集率及内皮细胞功能的影响。结果联合治疗组临床疗效总有效率87.9%，高于对照组的69.7%（P ＜0.05）；联合治疗组心电图总有效率优于对照组（P ＜0.05）；血小板聚集率明显降低（P ＜0.05）；ET-1明显降低，NO 及 FMD 明显升高（P ＜0.05）。结论益心康泰胶囊联合曲美他嗪可改善患者心绞痛症状，通过抗血小板聚集、保护内皮功能损伤发挥治疗老年不稳定型心绞痛的作用。

Yixin Kangtai capsule combined with Trimetazidine in elderly patients with unstable angina

Objective To study the clinical efficacy of Yixin Kangtai capsule combined trimetazidine in elderly patients with unstable angina. Methods The 66 elderly patients with unstable angina were randomly divided into con-trol group and Yixin Kangtai capsule combined trimetazidine group,33 cases in each group. The control group received conventional anti-anginal drug therapy;while combination therapy group received conventional anti-anginal medica-tion,and then gave Yixin Kangtai capsule combined trimetazidine. The course was one month. After the treatment,we observed the symptoms of angina,ECG ST-T,platelet aggregation rate and vascular endothelial function. Results Af-ter treatment,the total effective rate 87. 9% of the combination therapy group was higher than the control group 69. 7%(P < 0. 05);The total efficiency of electrocardiogram of combination therapy group was higher than the control group(P < 0. 05);Platelet aggregation of the combination therapy group were significantly lower(P < 0. 05);ET-1 of the combination therapy group were significantly reduced,and NO and FMD were significantly increased(P < 0. 05). Conclusion Yixin Kangtai capsule combined trimetazidine play an important role in elderly patients with unstable angina by improving the symptoms of angina,anti-platelet aggregation,protecting endothelial dysfunction.