Oral lormetazepam in premedication. A comparison with diazepam |
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Authors: | C-J Jakobsen MD J-J Jensen MD W Hansen MD N Grabe MD |
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Institution: | Department of Anaesthesia, Viborg Hospital, Section West, 8800 Viborg Denmark. |
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Abstract: | Lormetazepam, a relatively new benzodiazepine was compared in a randomised, double blind trial with diazepam for its effectiveness as an oral premedicant drug. A scoring system was used to assess sedation, relief of anxiety, nausea, dizziness and cardiovascular effects in two groups of patients having orthopaedic operations. Some statistical indication that lormetazepam has a greater anxiolytic effect than diazepam was found, but in assessing total effect using a known scoring system, no difference was demonstrated between the two drugs. |
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Keywords: | Premedication benzodiazepines diazepam lormetazepam |
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