Ovarian dysfunction,obesity and pituitary tumors in female mice following neonatal exposure to low-dose diethylstilbestrol |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, Ludwig-Maximilians-University, Munich, Germany;2. Department of Obstetrics and Gynecology, Charité Universitätsmedizin, Berlin, Germany;1. Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;2. Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;3. Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan;1. Medical Laboratories Technology Department, Faculty of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia;2. Biochemistry Department, Al-Azhar University, Nasr City, Cairo 11751, Egypt;3. Biochemistry and Molecular Medicine Department, College of Medicine, Taibah University, Saudi Arabia;4. Medical Biochemistry Department, Faculty of Medicine, Tanta University, Egypt;5. Clinical Pathology Department, National Cancer Institute, Cairo University, Egypt;6. Pharmacology &Toxicology Department, King AbdulAziz University, Jeddah, Saudi Arabia;1. Department of Biological Sciences, Wichita State University, Wichita, KS 67260-0026, United States;2. Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, United States;3. Bioinformatics Core, University of Kansas Medical Center, Kansas City, KS 66160, United States |
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| Abstract: | In a previous study, we found that early life exposure to low-dose diethylstilbestrol (DES) induced early onset of spontaneous abnormalities in estrus cycle and shortened survival in female Sprague-Dawley rats. In order to confirm the repeatability of the previous study, neonates of C57BL/6J mice were orally administered DES at doses of 0.005, 0.05, 0.5 and 5 μg/kg/day, and the aging of their reproductive function was observed. As a result, delayed toxicity on ovarian function was found in females treated with 0.5 μg/kg/day of DES. Concomitantly, the females in the 0.05 μg/kg/day of DES, or greater, groups, had increased body weights and, in the 0.5 μg/kg/day of DES, or greater, groups, had developed pituitary tumors, which were causal factors in their accelerated mortality. Thus, we found that early life exposure to low-dose DES induced early onset of spontaneous abnormalities in estrus cycle not only in female rats but also in female mice. |
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