维生素C对低硒高镉饲养大鼠心肌细胞电生理的影响

目的 进一步阐明微量元素硒镉含量异常是心肌细胞损害的机理。方法 用细胞内微电极技术分别观察了：正常对照、单纯高Cd、高Cd高维生素C、低Se高Cd、低Se高Cd伴高维生素C饲料饲养14w后大鼠心肌细胞电生理的变化。结果 单纯高镉组无变化。低硒并高匐组RP、APA降低，APD50、APD90明显延长；低Se高镉高维生素C组仅RP降低，APA、APD与对照组相比差异无显著性意义。结论 低硒并高可明显改变心肌细胞的电生理特性，维生素C可以对抗低Se并高Cd所致的这种变化。

Effects of vitamin c on the electrophysiological property of myocardial cells ofthe rats fed with low selenium and high cadmium fodder

Objective: To elucidate the etiology of the impairment of myocardial cells in the Keshan disease. Methods: With intracellular microelectrode technique, we observed the electrophysiological changes of the five groups of rats fed respectively with: normal, high Cd, high Cd high VC, low Se high Cd and low Se high Cd high VC fodder. Results:Compared with the control, there was no change in high Cd group. However, in low Se high Cd group, APA decreased, APD 50 and APD 90 prolonged significantly; in high vitamin C groups, though RP still decreased, no change had been detected on APA and APD. Conclusion: It is suggested that Se and Cd may jointly change the electrophysiological properties of myocardial cells significantly. However, vitamin C may protect myocardial cells against the injury effectively.