HPMA Copolymer-Aminohexylgeldanamycin Conjugates Targeting Cell Surface Expressed GRP78 in Prostate Cancer期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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HPMA Copolymer-Aminohexylgeldanamycin Conjugates Targeting Cell Surface Expressed GRP78 in Prostate Cancer

Authors:	Nate Larson Abhijit Ray Alexander Malugin Daniel B Pike " target="_blank">Hamidreza Ghandehari

Institution:	(1) Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84108, USA;(2) Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, Utah, 84108, USA;(3) Department of Bioengineering, University of Utah, Salt Lake City, Utah 84108, USA;(4) Departments of Pharmaceutics & Pharmaceutical Chemistry and Bioengineering, Utah Center for Nanomedicine Nano Institute of Utah, University of Utah, 383 Colorow Road, Room 343, Salt Lake City, Utah 84108, USA;

Abstract:	Purpose This study focused on the synthesis and in vitro characterization of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates for the delivery of geldanamycin to prostate cancer tumors. Conjugates were modified to incorporate WIFPWIQL peptide, which binds to cell-surface-expressed Glucose-regulated protein 78.

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