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Orbitofrontal cortex and impulsivity in borderline personality disorder: an MRI study of baseline brain perfusion |
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| Authors: | Robert Christian Wolf Philipp Arthur Thomann Fabio Sambataro Nenad Vasic Markus Schmid Nadine Donata Wolf |
| Affiliation: | 1. Center of Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Vo?stra?e 4, 69115, Heidelberg, Germany 2. Brain Center for Motor and Social Cognition, Italian Institute of Technology, Parma, Italy 3. Department of Psychiatry and Psychotherapy III, University of Ulm, Ulm, Germany 4. Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany |
| Abstract: | Behavioral and neuroimaging studies in patients with borderline personality disorder (BPD) have associated orbitofrontal cortex (OFC) dysfunction with distinct symptom clusters such as impulsivity. It is unclear, however, whether abnormal patterns of OFC activity are also present during resting-state conditions and whether OFC dysfunction is specifically associated with impulsivity in BPD. This study tested the hypothesis that BPD patients would exhibit changes of OFC baseline perfusion and explored the relationship between regional cerebral blood flow and distinct BPD symptom clusters, such as impulsivity, dissociation tension and depressive symptoms. Using continuous arterial spin labeling magnetic resonance imaging at 3 Tesla, we investigated 16 women with BPD according to DSM-IV criteria and 16 healthy female control participants during resting-state conditions. Between-group comparisons were conducted using an analysis of variance (p? |
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