Physical inactivity and chronic kidney disease in Australian adults: The AusDiab study |
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Authors: | Sarah L. White David W. DunstanKevan R. Polkinghorne Robert C. Atkins Alan Cass Steven J. Chadban |
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Affiliation: | a The George Institute for International Health, PO Box M201, Missenden Rd, Camperdown, NSW 2050, Australia b Central Clinical School, Faculty of Medicine, University of Sydney, Australia c Baker IDI Heart and Diabetes Institute, Caulfield, Australia d Department of Medicine, Monash Medical Centre, Melbourne, Australia e Department of Transplantation, Royal Prince Alfred Hospital, Sydney, Australia |
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Abstract: | Background and AimsPhysical inactivity is associated with cardiovascular risk however its relationship to chronic kidney disease is largely unknown. We examined the association between leisure-time physical activity and risk of chronic kidney disease in a prospective, population-based cohort of Australians aged ≥25 years (AusDiab).Methods and ResultsThe baseline sample included 10,966 adults (4951 males and 6015 females). From this sample, 6318 participants with complete baseline and 5-year follow-up urinalysis and serum creatinine measurements formed the study population for longitudinal analysis. Self-reported leisure-time physical activity was measured using a validated, interviewer-administered questionnaire. Compared with sufficiently active individuals (≥150 min physical activity per week), those who were inactive (0 min/week) were more likely to have albuminuria at baseline (multivariate-adjusted OR = 1.34, 95% CI 1.10-1.63). Inactivity (versus sufficient physical activity) was associated with increased age- and sex-adjusted odds of an estimated glomerular filtration rate <3rd percentile (OR = 1.30, 95% CI 1.02-1.65), although this was not significant after multivariate adjustment (OR = 1.17, 95% CI 0.91-1.50). Obese, inactive individuals were significantly more likely to have albuminuria at baseline (multivariate-adjusted OR = 1.74, 95% CI 1.35-2.25), compared with sufficiently active, non-obese individuals. Baseline physical activity status was not significantly associated with longitudinal outcomes.ConclusionsPhysical inactivity is cross-sectionally associated with albuminuria prevalence, particularly when combined with obesity. Future studies are needed to determine whether this association is causal and the importance of physical activity in CKD prevention. |
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Keywords: | Epidemiology Chronic kidney disease Physical activity Obesity Albuminuria Glomerular filtration rate |
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