p27和p-ERK1/2在胃癌中的表达和意义

目的 探讨p27和p-ERK1／2在胃癌中的表达，意义及二者可能的相互关系。方法 免疫组织化学（SP）法检测46例胃癌组织及10例正常胃黏膜中p27和p-ERK1／2的表达。结果 ①胃癌组织中p27阳性表达率28．3％（13／46）明显低于正常胃黏膜组织90％（9／10），其表达水平和组织分化程度、胃壁浸润深度、淋巴结转移等有关。②胃癌组织中p-ERK1／2的阳性表达率47．8％（22／46）明显高于正常胃黏膜组织10％（1／10），其表达水平和胃壁浸润深度、淋巴结转移、TNM分期等有关。③胃癌组织中p27和p-ERK1／2的表达呈明显负相关。结论 ERK1／2基因的活化可以调节p27的表达，二者与胃癌发生发展有关。

The expression and its signifinance of p27 and p-ERK1/2 proteins in gastric carcinoma

Objective To study the expression and its signifinance of p27 and p-ERK1/2 proteins in human gastric carcinoma.Methods The expressions of p27 and p-ERK1/2 proteins in 46 cases of gastric carcinoma and 10 cases of normal tissues were detected by immunohistochemistry technique.Results (1)Positive expression rate of p27 in gastric carcinoma was 28.3% (13/46),which was significantly lower than that in normal tissues(90%,P<0.01). The expression level of p27 was related to histological differentiation, extent of infiltrating, lymphnode metastasis(P<0.05). (2) Positive expression rate of p-ERK1/2 in gastric carcinoma was 47.8%(22/46),which was significantly higher than that in normal tissues(10%, P<0.05). The expression level of p-ERK1/2 was related to extent of infiltrating, lymphnode metastasis and TNM stage(P<0.05).(3)There was a significant inverse correlation in the expression of p27 and p-ERK1/2(P<0.05).Conclusion The activity of ERK1/2 can regulate the expression of p27 and both of them may play an important role in the genesis and development of gastric carcinoma.