| 艾灸对溃疡性结肠炎大鼠结肠及下丘脑辣椒素受体1表达的影响 |
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| 引用本文： | 口锁堂,吴焕淦.艾灸对溃疡性结肠炎大鼠结肠及下丘脑辣椒素受体1表达的影响[J].上海针灸杂志,2009,28(8):435-438. |
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| 作者姓名： | 口锁堂 吴焕淦 |
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| 作者单位： | 1. 上海市天山中医医院,上海,200051;上海中医药大学,上海,201203
2. 上海中医药大学,上海,201203 |
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| 基金项目： | 国家重点基础研究发展计划，国家自然科学基金重大研究计划面上项目 |
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| 摘 要： | 目的探讨麦粒灸对溃疡性结肠炎（ulcerative colitis,UC）大鼠结肠及下丘脑辣椒素受体1（VR1）的影响。方法采用免疫学方法加局部刺激制备实验性UC大鼠模型,随机分为模型组和治疗组,并与正常组作对照,治疗组施以麦粒灸治疗,采用免疫组化染色法观察结肠及下丘脑VR1的表达。结果与正常组比较,模型组大鼠结肠及下丘脑VR1的表达明显增强（P〈0.05）;与模型组比较,治疗组大鼠结肠及下丘脑VR1的表达明显降低（P〈0.05）。结论实验性UC模型大鼠结肠及下丘脑VR1增加,麦粒灸可以降低UC大鼠结肠及下丘脑VR1的表达。
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| 关 键 词： | 艾灸 结肠炎 溃疡性 下丘脑 结肠 辣椒素受体1 |
Effect of Moxibustion on Ulcerative Colitis Rats' Vanilloid Receptor Subtype 1 of Colon and Hypothalamus |
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| KOU Suo-tang,WU Huan-gan.Effect of Moxibustion on Ulcerative Colitis Rats'' Vanilloid Receptor Subtype 1 of Colon and Hypothalamus[J].Shanghai Journal of Acupuncture and Moxibustion,2009,28(8):435-438. |
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| Authors: | KOU Suo-tang WU Huan-gan |
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| Institution: | KOU Suo-tang1,2,WU Huan-gan2. 1.Shanghai Tianshan Hospital,Shanghai 200051,China,2.Shanghai University of Traditional Chinese Medicine,Shanghai 201203 |
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| Abstract: | Objective To investigate the effect of moxibustion on ulcerative colitis rats' vanilloid receptor subtype 1(VR1) of colon and hypothalamus. Methods The experimental rats model of ulcerative colitis were estabelished by immunological methods and local stimulation. Rats were randomly allocated to model group,treatment group and control group. The treatment group received moxibustion with seed-sized moxa cone. VR1 in colon and hypothalamus in the experimental rats were assayed with immunohistochemical staining... |
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| Keywords: | Moxibustion Colitis Ulcerative Hypothalamus Colon Vanilloid receptor subtype 1 |
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