| 结核分枝杆菌动物模型及其应用 |
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| 引用本文： | 刘芳,杨华,周文江,范晓勇. 结核分枝杆菌动物模型及其应用[J]. 实验动物与比较医学, 2009, 29(6): 429-434. DOI: 10.3969/j.issn.1674-5817.2009.06.019 |
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| 作者姓名： | 刘芳 杨华 周文江 范晓勇 |
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| 作者单位： | 1. 上海市公共卫生临床中心,上海,201508
2. 上海市公共卫生临床中心,上海201508;复旦大学实验动物科学部,上海200032 |
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| 基金项目： | 上海市科委"科技创新行动" |
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| 摘 要： | 随着WHO2009年全球结核控制报告的发布，结核病的深入研究迫在眉睫。传统的研究已经不能满足当今世界结核病形势的需要，诸如耐多药／广泛耐药结核病问题成为人们关注的焦点。理想的结核分枝杆菌（MTB）动物模型，对研究结核病的免疫发病机理，评估抗结核新药、疫苗和诊断试剂效价具有重要的意义。根据不同的研究目的和应用，现仅就已建立的各种结核分枝杆菌动物模型及其评价展开综述，并对结核动物模型的未来与发展作一展望。
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| 关 键 词： | 结核分枝杆菌 动物模型 急性感染 潜伏感染 合并感染 |
Animal Model of Mycobacterium Tuberculosis and the Application |
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| Affiliation: | LIU Fang, YANG Hua, ZHOU Wen-jiang, FAN Xiao-yong (1. Shanghai Public Health Clinical Center, Shanghai 201508, China; 2. Fudan University of Department of Laboratory Animal Science, Shanghai 200032, China) |
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| Abstract: | With the publication of the report on WHO 2009 Global Tuberculosis（TB） Control, deep study on TB is extremely urgent. Traditional research couldn＇t satisfy the needs of TB＇s situation today, such as the problem of MDR/XDR-TB which has became into focus of the people. Ideal animal models of MTB take important meaning for studying the immunopathogenesis of TB, as well as evaluating the effects of novel anti-TB drugs, vaccines and diagnostic reagent. According to different purpose of the study and application, here just given an overview of various animal models of Mycobacterium tuberculosis （MTB） which have been built, and also take a view of their future.. |
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| Keywords: | Mycobacterium tuberculosis Animal model Acute infection Latent infection Concurrent infection |
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