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多重肿瘤抑制基因p16在喉癌及边缘组织和声带息肉中表达的研究
引用本文:戴嵩 孙兴和. 多重肿瘤抑制基因p16在喉癌及边缘组织和声带息肉中表达的研究[J]. 中国肿瘤临床, 1998, 25(11): 824-826
作者姓名:戴嵩 孙兴和
作者单位:解放军第463医院耳鼻喉科
摘    要:目的:为了探讨p16基因在喉癌及边缘和声带息肉组织中的表达情况,研究其与喉癌临床间的关系。方法:采用免疫组化SABC方法对36例原发喉癌及边缘1.0cm组织和20例声带息肉组织中p16蛋白检测。结果:喉癌组10例阳性率27.8%,边缘组20例阳性率55.6%,息肉组8例阳性率40%。喉癌组与边缘组阳性率之间差异显著P<0.05,喉癌组中,阳性率明显高于强阳性率,两者之间差异明显,P<0.05。高分化组阳性率明显高于低分化组阳性率,P<0.05。p16蛋白的表达在喉癌的临床分期,肿瘤发生部位及是否有淋巴结转移间差异不明显。结论:p16基因在抑制喉癌细胞增殖分化过程中起着积极的作用

关 键 词:喉癌  声带息肉  p16基因

Study on Expression of Multiple Tumor Suppressor Gene p16 in Laryngeal Cancer and Its Adjacent Tissue and Vocal Cord Polyp
Dai Song Sun Xinghe Xu Zhenming Hospital of PLA,Shengyang. Study on Expression of Multiple Tumor Suppressor Gene p16 in Laryngeal Cancer and Its Adjacent Tissue and Vocal Cord Polyp[J]. Chinese Journal of Clinical Oncology, 1998, 25(11): 824-826
Authors:Dai Song Sun Xinghe Xu Zhenming Hospital of PLA  Shengyang
Affiliation:Dai Song Sun Xinghe Xu Zhenming 463 Hospital of PLA,Shengyang
Abstract:The expression of p16 gene protein was determined immunohistochemically in 36 cases of primary laryngeal cancer and their adjacent tissue (1.0cm to the tumor) and 20 cases of vocal cord polyp. The results showed that the positive rates were 27.8% in cancer, 55.6% in adjacent tissue groups and 40% in vocal cord polyps. There was significant statistic difference of positive rate between the cancer and adjacent tissue groups ( P <0.05). Of the cancer group, the case marked positive significantly outnumbered those marked strongly positive ( P <0.05). The positive rate of the well differentiated cases was significantly higher than that of the poorly differentiated ( P <0 .05).The expression of p16 did not show apparent association with the clinical staging or lymph node metastasis. The results suggested that p16 plays an important role in inhibiting proliferation and differentiation of laryngeal cancer cells.
Keywords:Laryngeal neoplasm Polyp of vocal cord Protein of gene p16  
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