Aspergillus Iris Granuloma: A Case Report with Review of Literature |
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Authors: | Vandana Jain Supriya Dabir Debraj Shome Tina Dadu Sundaram Natarajan |
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Affiliation: | 1 Department of Cornea and Anterior Segment, Orbital Diseases, and Ocular Oncology, Aditya Jyot Eye Hospital Pvt Ltd, Mumbai, India 2 Department of Retina, Orbital Diseases, and Ocular Oncology, Aditya Jyot Eye Hospital Pvt Ltd, Mumbai, India 3 Department of Ophthalmic and Facial Plastic Surgery, Orbital Diseases, and Ocular Oncology, Aditya Jyot Eye Hospital Pvt Ltd, Mumbai, India 4 Department of Ocular Oncology, Tata Memorial Centre, India 5 Department of Pathology, Sir Gangaram Hospital, New Delhi, India |
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Abstract: | We report the case of a 25-year-old male patient who presented with complaints of redness, photophobia, and decreased vision in the right eye of a week's duration. Slit-lamp biomicroscopic examination revealed a cream-colored, irregular elevated inferior iris mass, extending on to the anterior lens surface. Differential diagnoses of a fungal granuloma, a medulloepithelioma, and an amelanotic melanoma were considered. An excisional biopsy of the mass was performed through a superior clear corneal incision. Polymerase chain reaction analysis of the aqueous humor showed a positive pan fungal genome. Histopathology of the biopsied mass showed a giant cell granuloma with surrounding numerous branching, septate hyphae. Culture growth revealed Aspergillus fumigatus We report this case because of the rarity of Aspergillus iris granuloma as a primary presentation of endogenous Aspergillosis and review the relevant literature. Absence of a significant systemic history compounded the diagnostic dilemma in our patient. Definitive differentiation of this rare entity from a foreign body, amelanotic melanoma, and other inflammatory conditions such as sarcoidosis and tuberculosis, may be possible only on microbiological and histo-pathological evaluation. |
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Keywords: | Aspergillus fumigatus giant cell granuloma iris granuloma microbiological evaluation polymerase chain reaction |
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