| 丁丙诺啡对吗啡依赖大鼠的位置偏爱效应的影响 |
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| 引用本文： | 苏军凯,郑有顺,文磊,余林中,莫志贤.丁丙诺啡对吗啡依赖大鼠的位置偏爱效应的影响[J].中国药物依赖性杂志,2000,9(1):21-22. |
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| 作者姓名： | 苏军凯 郑有顺 文磊 余林中 莫志贤 |
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| 作者单位： | 第一军医大学中医系药理教研室!广州，510515，第一军医大学中医系药理教研室!广州，510515，第一军医大学中医系药理教研室!广州，510515，第一军医大学中医系药理教研室!广州，510515，第一军医大学中医系药理教研室!广州，510515 |
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| 摘 要： | 目的··:探讨丁丙诺啡对阿片类药物依赖的治疗作用。方法··:以生理盐水为对照组 ,应用丁丙诺啡对吗啡依赖大鼠进行脱毒治疗 ,分别于停用吗啡24h,72h,8d观察其对湿狗样抖动、齿颤等戒断症状的影响及位置偏爱实验吗啡侧停留时间。结果··:丁丙诺啡能明显地缓解和控制戒断症状 ,递减顺利 ,但不能改变大鼠在吗啡侧停留时间。结论··:丁丙诺啡脱毒治疗没有明显改变依赖大鼠对阿片类药物的精神依赖 ,临床应用中加强心理治疗对预防复吸非常重要
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| 关 键 词： | 丁丙诺啡 吗啡依赖 戒断综合征 位置偏爱 |
EFFECT OF BUPRENORPHINE ON THE CONDITIONED PLACE PREFERENCE OF MORPHINE-DEPENDENT RATS |
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| SU Junkai,ZHENG Youshun,WEN Lei,YU Linzhong,MO Zhixian.EFFECT OF BUPRENORPHINE ON THE CONDITIONED PLACE PREFERENCE OF MORPHINE-DEPENDENT RATS[J].Chinese Journal of Drug Dependence,2000,9(1):21-22. |
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| Authors: | SU Junkai ZHENG Youshun WEN Lei YU Linzhong MO Zhixian |
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| Abstract: | Objective: To study the efficacy of buprenorphine(Bup) on opioids dependence treatment. Method: Rats of dependence on morphine was treated with Bup; the scores of withdrawal symptoms and time spent in morphine-paired box was measured at the 24 hour, 72 hour and on the 8th day in test rates . Result: Bup could inhibit some withdrawal symptoms significantly, but could not change the time spent in the morphine-paired box. Conclusion: Bup can not change conditioned place preference of morphine. Psychological therapy is needed to prevent relapse opioids abuse. |
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| Keywords: | buprenorphine morphine dependence withdrawal symptom conditioned place preference |
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