氧化应激与帕金森老年患者运动功能的关系

目的：探究氧化应激对帕金森老年患者运动功能的影响。方法选取50例帕金森患者（实验组）、50例身体健康者（对照组）,检测Hoehn-Yahr（H-Y）不同分级患者和对照组血清微量元素以及血浆内与氧化应激相关的指标含量,包括丙二醛（ MDA）、超氧化物歧化酶（ SOD）、谷胱甘肽（ GSH）,观察实验组中患者的上述指标与其所处H-Y分级之间的关系。结果对照组血清内铜、锌的平均含量高于实验组,铅含量低于实验组;血浆内MDA平均含量低于实验组,SOD与GSH高于实验组;上述差异均有统计学意义（P＜0．05）。实验组患者中, H-Y1级8例,H-Y2级13例,H-Y3级17例,H-Y≥4级12例;患者所处Hoehn-Yahr分级与其血浆内MAD含量呈显著正相关,与SOD、GSH含量呈显著负相关（P＜0．05）。结论随着疾病发展,帕金森病症患者机体的抗氧化应激能力越来越差,运动障碍越严重。

Effect of oxidative stress on the physical activity of elderly patients of Parkinson's disease

Objective To explore the effect of oxidative stress on the physical activity of elderly patients with Parkinson 's disease.Method 50 patients with Parkinson's disease (experimental group) and 50 healthy persons (control group) were chosen as the subjects of study .The serum trace element and plasma levels of indicators related to oxidative stress in the control group and different Hoehn-Yahr(H-Y)grades, including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione ( GSH) were detected and then the index patient relationship with its live Hoehn-Yahr grade between the experimental group was observed .Findings The serum copper and the average content of zinc of the control group were statistically higher than those of the experimental group .The lead level in the control group was statistically lower than that of the experimental group .The average content of MDA in plasma of the control group was statistically lower than that of the experimental group .SOD in plasma and the average content of GSH of the control group were statistically higher than those of the experimental group.The differences were statistically significant (P<0.05).The experimental group was found to include 8 cases of H-Y1, 13 cases of H-Y2 13, 17 cases of H-Y3, and 12 cases with HY≥4 12 .In patients with Hoehn-Yahr classification and plasma the MAD content was significantly positively correlated with SOD while the GSH content was significantly negatively correlated ( P <0.05 ).Conclusion With the development of the disease , the ability of anti oxidative stress in patients with Parkinson's disease is getting worse and worse .