| 扶正消癌Ⅰ号方对FOLFOX4方案治疗晚期结直肠癌减毒增效的临床研究 |
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| 引用本文： | 胡艳,侯安继,周维,张红卫,黄燕莉,沈晓燕,周莉,顾魏峰.扶正消癌Ⅰ号方对FOLFOX4方案治疗晚期结直肠癌减毒增效的临床研究[J].上海中医药杂志,2009,43(2). |
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| 作者姓名： | 胡艳 侯安继 周维 张红卫 黄燕莉 沈晓燕 周莉 顾魏峰 |
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| 作者单位： | 上海市第七人民医院肿瘤科,上海,200137
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| 基金项目： | 上海市浦东新区中医中青年骨干培养基金 |
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| 摘 要： | 目的观察扶正消癌Ⅰ号方对FOLFOX4方案治疗晚期结直肠癌的减毒增效作用。方法将40例晚期结直肠癌患者随机分为研究组和对照组各20例,两组均采用FOLFOX4方案治疗,研究组同时给予扶正消癌Ⅰ号方。2周为1个治疗周期,6个周期后观察近期疗效、毒副反应、生存质量和中位生存期。结果研究组、对照组进入统计学处理的病例数分别为18例和17例。两组近期疗效分别为50.00%和41.18%,组间差异无统计学意义(P>0.05);研究组毒副反应发生率显著低于对照组(P<0.05),生存质量改善优于对照组(P<0.05);两组中位生存时间(MST)和总生存时间(OS)比较,差异无统计学意义(P>0.05)。结论扶正消癌Ⅰ号方对FOLFOX4方案治疗晚期结直肠癌能够显著降低毒副反应发生率,提高患者生存质量,具有肯定的减毒增效作用,有一定的临床应用价值。
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| 关 键 词： | 结直肠肿瘤 扶正消癌Ⅰ号方 化学疗法 减毒增效 |
Clinical Study on Attenuated and Synergistic Effects of "Fuzheng Xiaoai Decoction" in Treating Advanced Colorectal Cancer Patients Undergoing FOLFOX4 Regimen |
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| HU Yan HOU An-ji ZHOU Wei ZHANG Hong-wei HUANG Yan-li SHEN Xiao-yan ZHOU Li GU Wei-feng.Clinical Study on Attenuated and Synergistic Effects of "Fuzheng Xiaoai Decoction" in Treating Advanced Colorectal Cancer Patients Undergoing FOLFOX4 Regimen[J].Shanghai Journal of Traditional Chinese Medicine,2009,43(2). |
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| Authors: | HU Yan HOU An-ji ZHOU Wei ZHANG Hong-wei HUANG Yan-li SHEN Xiao-yan ZHOU Li GU Wei-feng |
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| Institution: | HU Yan HOU An-ji ZHOU Wei ZHANG Hong-wei HUANG Yan-li SHEN Xiao-yan ZHOU Li GU Wei-fengDepartment of Oncology,Shanghai Seventh People's Hospital |
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| Abstract: | Objective To study the attenuated and synergistic effects of "Fuzheng Xiaoai Decoction" in the treatment of advanced colorectal cancer patients undergoing FOLFOX4 regimen.Methods Forty subjects were randomized into two groups:control group in which 20 cases were treated by FOLFOX4 regimen and treatment group in which 20 cases were treated by combined FOLFOX4 regimen and "Fuzheng Xiaoai Decoction".After 12-week treatments,the near-term effect,toxic reaction,quality of life and median survival time(MST)were o... |
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| Keywords: | Colorectal cancer "Fuzheng Xiaoai Decoction" chemotherapy attenuated and synergistic effect |
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