Treatment of chronic hepatitis B |
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Authors: | A. S. F. Lok |
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Affiliation: | Section of Gastroenterologg and Hepatologg, Department of Medicitie, Tulane University and VA Medical Center, New Orleans, LA, USA |
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Abstract: | SUMMARY. Chronic infection with the hepatitis B virus (HBV) is a major cause of worldwide morbidity and mortality. A large number of therapeutic approaches has been tried, including interferon (IFN), nucleoside analogues and immunomodulators. To date controlled clinical trials have shown that only IFN is of long-term value but many patients fail to respond to treatment. New approaches to treating patients with IFN-resistant hepatitis B are currently undergoing clinical and experimental evaluation, and it seems likely that new therapeutic agents will be available in the near future. |
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Keywords: | chronic hepatitis B hepatitis B e antigen seroconversion hepatitis B surface antigen seroconversion hepatitis B virus DNA interferon therapy |
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