| MMP-9基因二核苷酸重复序列多态标志与2型糖尿病视网膜并发症相关 |
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| 引用本文： | 刘丽梅,项坤三,郑泰山,王延庆,张蓉,李鸣,陆惠娟,李杰. MMP-9基因二核苷酸重复序列多态标志与2型糖尿病视网膜并发症相关[J]. 中华内分泌代谢杂志, 2004, 20(5): 446-447 |
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| 作者姓名： | 刘丽梅 项坤三 郑泰山 王延庆 张蓉 李鸣 陆惠娟 李杰 |
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| 作者单位： | 200233,上海交通大学附属第六人民医院内分泌代谢科,上海市糖尿病研究所 |
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| 基金项目： | 国家自然科学基金资助项目 (3990 0 0 71 ) |
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| 摘 要： | 采用基因扫描方法 ,检测 2型糖尿病视网膜并发症患者 (DR )及无该并发症 (DR -)患者基质金属蛋白酶 9(MMP 9)基因二核苷酸串联重复序列多态标记 (AC)n的基因型。与DR -组相比 ,DR 组AC2 1基因型及等位基因频率显著减少 ,提示MMP 9基因的AC2 1等位基因可能与中国人 2型糖尿病视网膜并发症相关
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| 关 键 词： | 基因 基质金属蛋白酶9 串联重复序列 糖尿病 2型 糖尿病视网膜并发症 |
| 修稿时间： | 2004-03-29 |
A dinucleotide repeat polymorphism of matrix metalloproteinase-9 gene is associated with type 2 diabetic retinopathy |
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| Abstract: | The genotypes of (AC)n dinucleotide repeat polymorphism of matrix metalloproteinase-9 (MMP-9) were determined by gene scan method between type 2 diabetes mellitus with retinopathy (DR ) and without retinopathy (DR-). The AC 21 allelic and genotypic frequencies were significantly decreased in DR group as compared with DR- group, suggesting that AC 21 allele of the MMP-9 gene is associated with type 2 diabetic retinopathy in Chinese. |
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| Keywords: | Gene matrix metalloproteinase-9 Tandem repeat sequences Diabetes mellitus type 2 Diabetic retinopathy |
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