Alloplastic injectable biomaterials for soft tissue augmentation: a report on two cases with complications associated with a new material (DermaLive) and a review of the literature |
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| Authors: | E. Waris M. Pakkanen K. Lassila P. Törmälä Y. T. Konttinen R. Suuronen N. Ashammakhi |
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| Affiliation: | (1) Institute of Biomedicine/Anatomy, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland;(2) Siluetti, Helsinki, Finland;(3) Institute of Biomaterials, Tampere University of Technology, Tampere, Finland;(4) Department of Oral Medicine/Invärtes Medicin, Helsinki University Central Hospital, Finland;(5) Departments of Oral and Maxillofacial Surgery, University of Helsinki and Helsinki University Central Hospital, Finland |
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| Abstract: | A wide variety of biological and alloplastic injectable biomaterials are available for soft tissue augmentation, but the ideal material has not yet been discovered. Biological materials such as collagen and hyaluronan yield temporary results, while injectable alloplasts are apt to cause varying degrees of foreign body reactions that may result in lumps and chronic inflammation.We present two cases (one is the first filed case in the world) of migratory subcutaneous inflammatory masses secondary to injection of acrylic hydrogel (DermaLive), which is an alloplastic biomaterial recently introduced into the market in Europe. Histology revealed foreign body reaction to acrylic hydrogel with granuloma formation containing multinucleated giant cells. Following this, further reports on complications have been reported elsewhere in Europe. The use and development of injectable materials, as well as alternative methods and future directions are reviewed. |
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| Keywords: | Augmentation Acrylic hydrogel Complication Injectable biomaterial |
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