| TIL细胞治疗恶性胸水的疗效观察 |
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| 引用本文： | 陈建清,曾道林,康美玲,钟小红,董书春,刘进兵,吴晓安. TIL细胞治疗恶性胸水的疗效观察[J]. 中国肿瘤临床与康复, 2011, 0(1): 56-57 |
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| 作者姓名： | 陈建清 曾道林 康美玲 钟小红 董书春 刘进兵 吴晓安 |
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| 作者单位： | 解放军第一七四医院肿瘤中心二区; |
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| 摘 要： | 目的观察肿瘤浸润淋巴细胞(TIL)治疗恶性胸水的疗效。方法从30例恶性肿瘤胸水中的肿瘤细胞分离得到TIL,并经10%人AB血清RPM I-1640液培养,经rIL-2体外激活培养,随后胸腔注射。结果完全缓解12例(40.0%),有效15例(50.0%),无效3例(10.0%),总有效率90.0%(27/30)。结论 TIL治疗恶性胸腔积液疗效好,毒副作用小,能改善患者的生活质量。
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| 关 键 词： | 恶性肿瘤 肿瘤浸润细胞 白细胞介素-2 胸腔积液 穿刺术 |
Observation of efficacy of tumor infiltrating lymphocytes in treatment of malignant pleural effusion |
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| CHEN Jian-qing,ZENG Dao-lin,KANG Mei-ling,et al. Observation of efficacy of tumor infiltrating lymphocytes in treatment of malignant pleural effusion[J]. Chinese Journal of Clinical Oncology and Rehabilitation, 2011, 0(1): 56-57 |
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| Authors: | CHEN Jian-qing ZENG Dao-lin KANG Mei-ling et al |
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| Affiliation: | CHEN Jian-qing,ZENG Dao-lin,KANG Mei-ling,et al(The Second Ward of Oncology Department,174th PLA Hospital,Xiamen 361003,China) |
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| Abstract: | Objective To evaluate the efficacy of tumor infiltrating lymphocytes(TIL)in treatment of patients with malignant pleural effusion.Methods TILs derived from malignant pleural effusion of 30 patients were cultivated in 10% human AB type serum RPMI-1640 liquid medium,activated by rIL-2 in vitro and injected into thoracic cavities.Results CR 12(40.0%),PR 15(50.0%),NR 3(10.0%).Conclusion The result suggests that TILs derived from malignant pleural effusion have good therapeutic efficacy and is safe in patients w... |
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| Keywords: | Malignant tumor Tumor infiltrating lymphocytes(TIL) Interleukin 2(IL-2) Pleural effusion Puncture |
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