| XELOX方案治疗晚期结直肠癌临床观察 |
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| 引用本文： | 张华,翟福林,王小军,邹勇斌.XELOX方案治疗晚期结直肠癌临床观察[J].中国肿瘤临床与康复,2011(1):53-55. |
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| 作者姓名： | 张华 翟福林 王小军 邹勇斌 |
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| 作者单位： | 郴州市第一人民医院南院肿瘤科; |
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| 摘 要： | 目的比较卡培他滨(希罗达)联合奥沙利铂(XELOX)方案与亚叶酸钙、氟尿嘧啶(5-Fu)联合奥沙利铂(FOLFOX4)方案一线治疗晚期转移性结直肠癌的疗效和不良反应。方法将56例晚期结直肠癌患者随机分为两组,XELOX方案组(28例):卡培他滨(capecitabine,Xeloda)1000mg/m2,Bid,口服,d1~14;奥沙利铂(oxaliplatin)130mg/m2,静脉滴注,持续2h,d1;21 d为1周期。FOLFOX4方案组(28例):奥沙利铂85 mg/m2,静脉点滴2 h,d1;醛氢叶酸200 mg/m2,静脉点滴2 h,d1、2;氟尿嘧啶400 mg/m2,莫非氏管静脉推注d1、2;氟尿嘧啶600 mg/m2,静脉持续滴注(化疗泵),持续22 h,d1、2,14 d为1周期。结果 XELOX组总有效率(RR)50.0%,中位肿瘤进展时间(TTP)7.0个月;FOLFOX4组RR为46.4%,TTP为6.8个月;两组比较各项指标差异无显著性(P>0.05)。不良反应中XELOX组手足综合征发生率高于FOLFOX4组,Ⅲ、Ⅳ度中性粒细胞减少发生率低于FOLFOX4组。结论 XELOX方案一线治疗晚期结直肠癌有确切疗效,不良反应可耐受,与FOL-FOX4方案相当,但XELOX方案用药更为方便,安全性更好。
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| 关 键 词： | 结直肠肿瘤 卡培他滨 奥沙利铂 |
Clinical observation of treatment of advanced colorectal cancer with XELOX regimen |
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| ZHANG Hua,ZHAI Fu-lin,WANG Xiao-jun,et al.Clinical observation of treatment of advanced colorectal cancer with XELOX regimen[J].Chinese Journal of Clinical Oncology and Rehabilitation,2011(1):53-55. |
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| Authors: | ZHANG Hua ZHAI Fu-lin WANG Xiao-jun |
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| Institution: | ZHANG Hua,ZHAI Fu-lin,WANG Xiao-jun,et al(Department of Oncology,South Branch of Chenzhou First People′s Hospital,Chenzhou 423000,China) |
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| Abstract: | Objective To compare the clinical efficacy and toxicity of XELOX regimen and FOLFOX4 regimen as the first-line chemotherapy of metastatic colorectal cancer.Methods Fifty-six metastatic colorectal cancer patients were randomly assigned to two groups:XELOX and FOLFOX4 groups.In XELOX group,the patients were treated with capecitabine 1000 mg/m2 orally twice everyday from day 1 to day 14,oxaliplatin 130 mg/m2 iv gtt for 2 hours on day 1,repeated every 3 weeks.In FOLFOX4 group,oxaliplatin 85 mg/m2 iv gtt for 2 h... |
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| Keywords: | Colorectal neoplasms Capecitabine Oxaliplatin |
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