| 骨痹舒片对实验性膝骨关节炎病理形态及自由基的影响 |
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| 引用本文： | 秦梦,王和鸣,娄玉钤.骨痹舒片对实验性膝骨关节炎病理形态及自由基的影响[J].中国中医骨伤科杂志,2011(3):1-3. |
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| 作者姓名： | 秦梦 王和鸣 娄玉钤 |
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| 作者单位： | 福建中医药大学;河南风湿病医院; |
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| 摘 要： | 目的:观察骨痹舒片对实验性膝骨关节炎病理形态的影响及对血清自由基的调节。方法:SD大鼠40只,采用改良Hulth法复制膝骨性关节炎模型,随机分为空白组、模型组、骨痹舒组、抗骨增生组,每组10只。每日灌胃1次,连续6周。6周后取股骨内髁关节软骨,经苏木-伊红、Masson、Safranin-O染色,光镜观察并行Mankin’s评分;测血清SOD、MDA、NO含量。结果:Mankin’s评分:模型组10.13±2.357,骨痹舒组6.75±1.753,组间比较差异有统计学意义(P<0.05);血清SOD、MDA、NO含量模型组分别为:21.315±8.633,12.619±1.51,70.125±3.786;骨痹舒组为:50.761±7.428,6.853±5.053,54.171±4.125,组间比较差异有统计学意义(P<0.05)。结论:骨痹舒片可通过提高SOD活性、有效清除氧自由基,抑制NO的过量释放及生物学效应,发挥减轻软骨破坏,延缓关节软骨退变的作用。
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| 关 键 词： | 骨关节炎 骨痹舒片 中药软骨 |
Effect of Gubishu Tablet on Pathomorphology and Free Radical of Experimental Knee Osteoarthritis |
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| QIN Meng WANG Heming LOU Yuqian,Fujian University of Traditional Chinese Medicine Henan Hospital of Rheumatism.Effect of Gubishu Tablet on Pathomorphology and Free Radical of Experimental Knee Osteoarthritis[J].Chinese Journal of Traditional Medical Traumatology & Orthopeics,2011(3):1-3. |
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| Authors: | QIN Meng WANG Heming LOU Yuqian Fujian University of Traditional Chinese Medicine Henan Hospital of Rheumatism |
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| Institution: | QIN Meng 1 WANG Heming 1 LOU Yuqian 2 1 Fujian University of Traditional Chinese Medicine 2Henan Hospital of Rheumatism |
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| Abstract: | Objective: To observe the effect of Gubishu Tablet on pathomorphology and free radical of experimental knee osteoarthritis(OA).Methods: Forty SD rats were randomly divided into 4 groups,blank group,model group,Gubishu group,and Kanggu Zengsheng group.Knee OA models were made by the modified Hulth method.Every group received a daily intragastric administration for 6 weeks,and then the articular cartilage of medial epicondyle femur was harvested to observe the pathological changes microscopically through the ... |
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| Keywords: | Osteoarthritis Gubishu troche Chinese herbal medicine Cartilage |
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