| N-三甲基壳聚糖包衣阿霉素脂质体与普通脂质体的抗肿瘤活性比较 |
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| 引用本文： | 何文,王小芹,冯敏. N-三甲基壳聚糖包衣阿霉素脂质体与普通脂质体的抗肿瘤活性比较[J]. 中国医院药学杂志, 2011, 0(2) |
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| 作者姓名： | 何文 王小芹 冯敏 |
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| 作者单位： | 武汉大学人民医院药学部;武汉大学药学院; |
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| 摘 要： | 目的:比较N-三甲基壳聚糖(TMC)包衣的盐酸阿霉素(ADM)脂质体与普通ADM脂质体的抗肿瘤活性。方法:采用硫酸铵梯度法制备ADM脂质体,以不同取代度的TMC进行包衣,采用动物移植性肿瘤实验法,用小鼠H22肝癌细胞接种于小鼠右侧腋下皮下形成实体瘤,考察TMC包衣ADM脂质体和普通脂质体给药后对实体瘤的瘤重抑制率。结果:TMC60、TMC40、TMC20包衣ADM脂质体对小鼠H22肝癌移植瘤的抑瘤率分别为64.3%,57.0%和54.8%,显著高于ADM脂质体组和游离ADM组(36.4%、42.7%)(P<0.05)。结论:TMC包衣ADM脂质体具有较好的抗肿瘤活性。
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| 关 键 词： | N-三甲基壳聚糖 阿霉素 脂质体 H22肝癌 肿瘤抑制率 |
Comparison of the anti-tumour activity between N-trimethyl chitosan-coated adriamycin liposomes and regular adriamycin liposomes |
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| HE Wen,WANG Xiao-qin,FENG Min. Comparison of the anti-tumour activity between N-trimethyl chitosan-coated adriamycin liposomes and regular adriamycin liposomes[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(2) |
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| Authors: | HE Wen WANG Xiao-qin FENG Min |
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| Affiliation: | HE Wen1,WANG Xiao-qin2,FENG Min2 (1.Department of pharmacy of Remin Hospital of Wuhan University,Hubei Wuhan 430060,China,2.College of pharmacy of Wuhan University,Hubei Wuhan 430072,China) |
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| Abstract: | OBJECTIVE To comparison of the anti-tumour activity between N-trimethyl chitosan(TMC)-coated adriamycin(ADM) liposomes and regular ADM liposomes.METHODS ADM liposomes were prepared by ammonium sulphate gradient method and coated by TMC with different degree of quarternization(DQ).The animal model of implantation of solid tumor was applied to evaluate the anti-tumor effect of TMC-coated ADM liposomes and regular ones by subcutaneous injection of murine hepatoma cells(H22) into the right limb armpit of mice.R... |
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| Keywords: | N-trimethyl chitosan adriamycin liposomes H22 hepatocarcinoma inhibitory rate on tumor |
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