门冬氨酸鸟氨酸颗粒剂对慢性肝病患者血清谷氨酰转肽酶水平的影响

目的观察门冬氨酸鸟氨酸颗粒剂（瑞甘）对慢性肝病患者血清谷氨酰转肽酶（GGT）水平的影响。方法应用瑞甘治疗慢性肝病血清GGT持续升高的患者,以双环醇（百赛诺）为对照组,疗程30天。结果 50例治疗组患者治疗前GGT水平为196.98±190.80U/L,治疗后为96.10±89.84 U/L（P〈0.01）,30例对照组治疗前为168.06±87.10U/L,治疗后为117.30±52.63U/L（P〈0.05）;两组GGT水平,治疗前比较无明显差异,治疗后比较也无明显差异;GGT水平与ALT呈正相关（r=0.40,P〈0.001）。结论瑞甘与双环醇均能明显降低慢性肝病患者血清GGT水平,有减轻肝脏炎症损害,保护肝脏的作用,两药对GGT水平的作用相当。

Effects of ornithine aspartate granules on the level of serum gamma-glutamyltransferase in patients with chronic liver diseases

Objective To investigate the effects of ornithine aspartate granules on the level of serum gamma-glutamyltransferase（GGT） in patients with chronic liver diseases.Methods The patients with high level of serum GGT with chronic liver diseases were treated by oral ornithine aspartate granules while the control group were treated by oral bicyclol tablets for 30 days.Results The GGT level before and after treatment were 196.98±190.80 U/L and 96.10±89.84 U/L in ornithine aspartate treatment group（P0.01）,while the GGT level were 168.06±87.10 U/L and 117.30±52.63 U/L in bicyclol treatment group（P0.05）,respectively.However,the GGT leves in both groups was not significantly different.The GGT levels were positively related to the ALT levels（P0.001）in both groups.Conclusions Ornithine aspartate granules and bicyclol tablets can reduce serum GGT level and improve inflammation of the liver damage in patients with high level of serum GGT with chronic liver diseases.