基因1型慢性丙型肝炎初治患者获得持续病毒学应答的相关因素研究

目的研究接受长效干扰素和利巴韦林治疗的基因1型慢性丙型肝炎患者获得持续病毒学应答的预测因素。方法 73例基因1型慢性丙型肝炎患者接受干扰素α-2a联合利巴韦林治疗24周或48周,随访6个月。结果 47.9%患者获得早期病毒学应答,38.4%患者获得持续病毒学应答;分析表明治疗前低病毒载量（小于8×105IU/ml）、体重指数低于25kg/m2和出现早期病毒学应答者更容易获得持续病毒学应答。结论病毒载量、体重指数和是否出现早期病毒学应答与基因1型慢性丙型肝炎初治患者获得持续病毒学应答相关。

Factors of sustained virologic response in de novo patiants with chronic hepatitis C genotype 1

Objective To study the related factors of a sustained virologic response in patients with chronic hepatitis C genotype 1.Method A total of 73 de novo chronic hepatitis C genotype 1 patients received combination therapy of peginterferon alpha and ribavirin for 24 to 48 weeks and were followed-up for 24 weeks.Results 47.9% of patient achieved an early viral response and 38.4% of patients got an sustained viral response;Statistical analysis indicated that patients with lower baseline HCV load（8×105 IU/ml）,lower body mass index and early viral response would achieve sustained viral response（SVR）.Conclusion Baseline HCV load,BMI and early viral response are related to achieving SVR in de novo hepatitis C genotype 1 patients.