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| 补体C5基因多态性与肝硬化发病的关系研究 | |
| 引用本文： | 李长政,郭水龙,李青山,王志强,王瑞玲,闫军红,蒋仁秀,程留芳.补体C5基因多态性与肝硬化发病的关系研究[J].实用肝脏病杂志,2011,14(6):427-429. |
| 作者姓名： | 李长政 郭水龙 李青山 王志强 王瑞玲 闫军红 蒋仁秀 程留芳 |
| 作者单位： | 1. 第二炮兵总医院消化科,北京市,100088 2. 解放军总医院老年医学研究所 3. 解放军总医院消化科 |
| 摘 要： | 目的探讨补体C5基因多态性与肝硬化发生的关系。方法慢性乙型肝炎和乙型肝炎肝硬化患者182例,提取白细胞DNA,采用Taqman实时PCR法进行C5基因rs17611位点的多态性基因型检测。结果在182例患者中,基因型为GG型者83例（45.6%）,AG型者79例（43.4%）,AA型者20例（11.0%）;肝硬化患者C5基因rs17611位点AA基因型检出率较高;多元Logistic回归分析显示AA基因型是肝硬化发生的独立危险因子（OR=5.1,P=0.008）。结论补体C5基因多态性可能与乙型肝炎病毒感染者发生肝硬化有关。 |
| 关 键 词： | 肝硬化 慢性乙型肝炎 补体C5 基因多态性 |
Polymorphism of complement C5 gene and susceptibility to liver cirrhosis in patients with chronic hepatitis B |
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| Institution: | LI Changzheng,Guo Shuilong,LI Qingshan,et al.General Hospital,Second Artillery Compound,Beijing 100088,China |
| Abstract: | Objective To evaluate the relationship of polymorphism of complement C5 gene and occurrence of liver cirrhosis in patients with chronic hepatitis B.Method Polymorphism of complement C5 gene rs17611 was examined in 182 Chinese patients with chronic hepatitis B or liver cirrhosis by using TaqMan PCR genotyping method.Results Patients with genotypes G/G,A/G and A/A were detected with A/A genotype higher in patients with liver cirrhosis（P=0.022）;By multivariate logistic regression analysis,genotype A/A was an independent factor associated with liver cirrhosis（odds ratio=5.1,P=0.008）.Conclusion Polymorphism of complement C5 gene rs17611 is associated with progression of liver disease in Chinese patients with hepatitis B virus infection. |
| Keywords: | Hepatitis B Liver cirrhosis Complement C5 Polymorphism |
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