| 细胞间黏附分子-1在中枢神经系统疾病中的表达和调控 |
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| 引用本文： | 孙丹,刘智胜. 细胞间黏附分子-1在中枢神经系统疾病中的表达和调控[J]. 实用儿科临床杂志, 2010, 0(7) |
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| 作者姓名： | 孙丹 刘智胜 |
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| 作者单位： | 武汉市儿童医院神经内科; |
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| 基金项目： | 武汉市青年科技晨光计划项目(20015005050) |
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| 摘 要： | 细胞间黏附分子-1(ICAM-1)分布于体内多种组织细胞表面,是具有广泛生物学活性的一种黏附因子,在炎症与免疫应答、信号转导、组织修复等多种生理与病理过程中起重要作用。现就ICAM-1在体内的表达与调控,以及其在某些中枢神经系统疾病发病中的作用作一综述。
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| 关 键 词： | 细胞黏附分子-1 黏附因子 中枢神经系统疾病 |
Expression and Regulation of Intercellular Adhesion Molecule-1 in Central Nervous System Diseases |
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| SUN Dan,LIU Zhi-sheng. Expression and Regulation of Intercellular Adhesion Molecule-1 in Central Nervous System Diseases[J]. Journal of Applied Clinical Pediatrics, 2010, 0(7) |
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| Authors: | SUN Dan LIU Zhi-sheng |
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| Affiliation: | SUN Dan,LIU Zhi-sheng(Department of Neurology,Wuhan Children's Hospital,Wuhan 430016,Hubei Province,China) |
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| Abstract: | Intercellular adhesion molecule-1 (ICAM-1) is found in surface of cells in various tissues,which is a adhesion molecule with wide range of biological activity and plays an important role in inflammatory and immune response,signal transduction,tissue repair and many other physiological and pathological processes.In this paper,ICAM-1 expression and regulation in the body,as well as some actions in the pathogenesis of central nervous system diseases are reviewed. |
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| Keywords: | cell adhesion molecule-1 adhesion molecule central nervous system disease |
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