| ~(99m)Tc-MIBI联合~(99m)Tc-HL91乏氧显像对60例原发性肺癌的诊断评价 |
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| 引用本文： | 张金山,吴兆红,邓咏梅,李敏,林炎彬,黄桂敏.~(99m)Tc-MIBI联合~(99m)Tc-HL91乏氧显像对60例原发性肺癌的诊断评价[J].国际放射医学核医学杂志,2006(5). |
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| 作者姓名： | 张金山 吴兆红 邓咏梅 李敏 林炎彬 黄桂敏 |
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| 作者单位： | 广州医学院第三附属医院核医学科，广州医学院第三附属医院心胸外科，广州医学院第三附属医院核医学科，广州医学院第三附属医院核医学科，广州医学院第三附属医院核医学科，广州医学院第三附属医院核医学科 |
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| 基金项目： | 广州市医药卫生科技资助项目(2004-37) |
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| 摘 要： | 目的探讨~(99m)Tc-甲氧基异丁基异腈(~(99m)Tc-MIBI)肺亲肿瘤显像联合~(99m)Tc-4,9-二氮- 3,3,10,10-四甲基十二烷-2,11-二酮肟(~(99m)Tc-HL91)乏氧显像对原发性肺癌的诊断效能。方法对60例拟诊断原发性肺癌患者,术前进行~(99m)Tc-MIBI及~(99m)Tc-HL91显像,以病理结果为金标准,分析~(99m)Tc-MIBI联合~(99m)Tc-HL91显像对原发性肺癌的诊断价值。结果病理结果证实原发性肺癌48例,良性病变12例。~(99m)Tc-MIBI、~(99m)Tc-HL91和~(99m)Tc-MIBI ~(99m)Tc-HL91显像对原发性肺癌诊断的灵敏度、特异度和准确率分别为89．6%(43/48)、77．1%(37/48)、95．8%(46/48),75．0%(9/12)、91．7%(11/12)、83．3%(10/12)和86．7%(52/60)、80．0%(48/60)、93．3%(56/60)。结论~(99m)Tc-MIBI肺亲肿瘤显像联合~(99m)Tc-HL91乏氧显像有助于提高对原发性肺癌的诊断效能。
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| 关 键 词： | 肺肿瘤 体层摄影术，发射型计算机，单光子 ~(99m)Tc-甲氧基异丁基异腈 ~(99m)Tc-HL91 |
The diagnostic value of ~(99m)Tc-MIBI combined with ~(99m)Tc-HL91 hypoxia imaging in primary lung cancer |
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| ZHANG Jin-shan WU Zhao-hong DENG Yong-mei LI Min LIN Yan-bin HUANG Gui-min.The diagnostic value of ~(99m)Tc-MIBI combined with ~(99m)Tc-HL91 hypoxia imaging in primary lung cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2006(5). |
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| Authors: | ZHANG Jin-shan WU Zhao-hong DENG Yong-mei LI Min LIN Yan-bin HUANG Gui-min |
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| Institution: | ZHANG Jin-shan~1 WU Zhao-hong~2 DENG Yong-mei~1 LI Min~1 LIN Yan-bin~1 HUANG Gui-min~1 |
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| Abstract: | Objective To assess the diagnostic value of ~(99m)Tc-sestamibi (~(99m)Tc-MIBI)combined with ~(99m)Tc labeled 4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-diane dioxime (~(99m)Tc-HL91) hypoxia imaging in primary lung cancer.Methods 60 patients with suspicious lung turnouts underwent ~(99m)Tc-MIBI and ~(99m)Tc- HL9l imaging before operation.The diagnosis were confirmed with pathological study after surgeries.The diagnostic effectiveness of ~(99m)Tc-MIBI and ~(99m)Tc-HL9l in primary lung cancer were analyzed.Results 48 patients were found primary lung cancer with pathological study,other 12 patients were benign.The sensitivity,speceifity and accuracy obtained with ~(99m)Tc-MIBI,~(99m)Tc-HL9l imaging and the combination of two methods were 89.6%(43/48),77.1%(37/48),95.8%(46/48);75.0%(9/12),91.7%(56/60),83.3%(10/12) and 86.7%(52/60),80.0%(48/60),93.3%(56/60),respectively.Conclusion The combination of ~(99m)Tc-MIBI and ~(99m)Tc-HL9l hypoxia imaging may increase the the diagnostic effectiveness in primary lung cancer. |
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| Keywords: | Lung neoplasms Tomography emission-computed single-photon ~(99m)Tc-sestamibi ~(99m)Tc-HL91 |
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