天然环菠萝蜜烷三萜化合物生物活性研究进展

环菠萝蜜烷三萜广泛存在于自然界,主要分布在豆科的紫云英属、毛茛科的升麻族和唐松草属等,具有多种生物学活性。随着植化分离手段的提高,越来越多的该类化合物被分离鉴定出来。然而,对于该类化合物生物活性的研究相对滞后,大多处于初筛阶段,缺乏作用机制的研究、体内实验的佐证以及它们构效关系的分析总结。作者从抗肿瘤、抗病毒、抗菌抗炎、免疫调节、心血管系统以及肝损伤保护等方面对该类化合物的生物活性进行总结,有利于对该类化合物更好的研究和开发。

Review of bioactivities of natural cycloartane triterpenoids

Cycloartane triterpenoids,which exist widely in nature,are mainly distributed in Astragalus(Leguminosae) species,Trib.Cimicifuga(Ranunculaceae) and Thalictrum(Ranunculaceae) species and possess various bioactivities.Along with the development of isolation techniques of phytochemistry,more and more this kind of compounds are isolated and identified.However,bioactivity researches on the compounds are relatively lagged behind.Most researches are still in screening level,deficient in mechanism elucidation,short of action proven in vivo and SAR analysis.The author summarized the bioactivity of this kind of compounds from all aspects: anti-tumor,anti-virus,antibacterial,anti-inflammation,immune-regulatory,cardiovascular system,hepatic protection and so forth.This will be benefit for the further research and development of the compounds.