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Successful transplantation of ethnically mismatched cord blood in a boy with atypical chronic myeloid leukemia |
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| Authors: | Tang-Her Jaing Iou-Jih Hung Shih-Hsiang Chen Wen-I Lee Yu-Chuan Wen En-Chen Fang |
| Affiliation: | 1. Division of Hematology and Oncology, Department of Pediatrics, Chang Gung Children’s Hospital, Chang Gung University, 5 Fu-Shin Street, Kwei-Shan, 333, Taoyuan, Taiwan 2. Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Chang Gung Children’s Hospital, Chang Gung University, Taoyuan, Taiwan 3. Department of Nursing, Chang Gung University and Memorial Hospital, Taoyuan, Taiwan |
| Abstract: | In the present study, we describe unrelated umbilical cord blood transplantation (CBT) in a 7-year-old Taiwanese boy with atypical chronic myeloid leukemia (BCR-ABL 1 negative). Physical examination was notable for splenomegaly. Cytogenetic analyses from the bone marrow revealed a t(3;5)(p21;q31) translocation. The patient then underwent CBT from an HLA-mismatched (two loci by serotype, three loci by genotype) unrelated donor of Caucasian origin. Times to neutrophil and platelet engraftment were 21 and 62 days post-transplant, respectively. Acute graft-versus-host disease following transplantation was minimal. The patient remains in continuing hematological remission with full donor chimerism 28 months after transplantation. |
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