| 蛞蝓提取物对肺癌细胞P53及端粒酶基因hTERT表达的影响 |
| |
| 引用本文： | 韦金育,曾振东,曾翠琼,杨增艳,俸曙光.蛞蝓提取物对肺癌细胞P53及端粒酶基因hTERT表达的影响[J].四川中医,2012(2):60-62. |
| |
| 作者姓名： | 韦金育 曾振东 曾翠琼 杨增艳 俸曙光 |
| |
| 作者单位： | 广西民族医药研究院,广西南宁530001 |
| |
| 基金项目： | 国家自然科学基金资助项目（编号：30960508） |
| |
| 摘 要： | 目的:了解蛞蝓提取物对肺癌细胞P53、端粒酶基因hTERT表达的影响。方法:体外培养肺癌细胞株,用免疫组化SP法进行检测。结果:蛞蝓提取物可抑制肺癌A549细胞端粒酶基因hTERT表达,并改变突变型P53表达。结论:蛞蝓提取物对肺癌细胞的抑制作用有可能是通过抑制突变型P53及端粒酶基因hTERT表达而实现的。
|
| 关 键 词： | 人肺癌细胞 端粒酶 蛞蝓 P53 |
Effect of Land Slug Extractive on Expression of P53 and hTERT Gene of Lung Cancer Cell |
| |
| WEI Jinyu,ZENG Zhendong,ZENG Cuiqiong,YANG Zengyan,FENG Shuguang.Effect of Land Slug Extractive on Expression of P53 and hTERT Gene of Lung Cancer Cell[J].Journal of Sichuan of Traditional Medicine,2012(2):60-62. |
| |
| Authors: | WEI Jinyu ZENG Zhendong ZENG Cuiqiong YANG Zengyan FENG Shuguang |
| |
| Institution: | Guangxi Institute Of Folk Medicine(Nanning Guangxi 530001,China) |
| |
| Abstract: | Objective： To find out the effect of land slug extractive on P53 and hTERT gene expression.Methods： Lung cancer cell lines in vitro was detected by immunohistochemistry SP method.Results： Land slug extractive could inhibit the expression of P53 and hTERT gene,and change expression of the Mutant P53.Conclusion： Land slug extractive possesses the inhibitory effects on Lung cancer cell may be realized by inhibiting the expression of P53and hTERT gene. |
| |
| Keywords: | Lung cancer cell hTERT Land slug P53 |
| 本文献已被 CNKI 维普 等数据库收录！ |
