Success of ampicillin plus ceftriaxone rescue therapy for a relapse of Enterococcus faecalis native-valve endocarditis and in vitro data on double beta-lactam activity |
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| Authors: | Miro Jose M Cervera Carlos Garcia-de-la-Maria Cristina Del Rio Ana Armero Yolanda Mestres Carlos A Grau Jose M Marco Francesc Moreno Asuncion |
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| Affiliation: | Infectious Diseases Service, Hospital Clinic, Helios Building, Desk no. 26, Villarroel 170, 08036 Barcelona, Spain. jmmiro@ub.edu |
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| Abstract: | We report a patient with Enterococcus faecalis native-valve endocarditis who relapsed after 4 weeks of treatment with ampicillin plus gentamicin. The relapse was cured with ampicillin plus ceftriaxone, which was introduced after gentamicin-induced acute renal failure. This double beta-lactam combination showed a bactericidal effect in time-killing curve studies. |
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