| Abstract: | An alcoholic extract of freshly collected Eclipta alba exhibited dose-dependent (62.5–500.0 mg/kg p.o.) significant hepatoprotective activity against carbon tetrachloride-induced liver injury in rats and mice. It indicated its protective role on parameters such as hexobarbitone-induced sleep, zoxazolamine-induced paralysis, bromosulphalen (BSP) clearance, serum levels of transaminases, bilirubin and protein. The extract did not show any signs of toxicity and the minimum lethal dose was greater than 2.0 g/kg when given orally and intraperitoneally in mice. |
