长春西汀联合巴曲酶对老年2型糖尿病伴耳聋患者听力、血糖及血清visfatin与ENA-78水平的影响

目的 探讨长春西汀联合巴曲酶对老年2型糖尿病伴耳聋患者听力、血糖及血清visfatin与ENA-78水平的影响.方法 选取2016年7月至2019年7月我院收治的94例老年2型糖尿病伴耳聋患者,按随机数表法分为观察组与对照组,每组47例.所有患者均予降糖、改善耳蜗微循环、营养神经等基础治疗.对照组应用巴曲酶注射液,静脉...

Effects of vinpocetine combined with batroxobin on blood glucose,hearing,and serum levels of visfatin and ENA-78 in elderly patients with type 2 diabetes mellitus and deafness

Objective To investigate the effects of vinpocetine combined with batroxobin on hearing,blood glucose,and serum levels of visfatin and ENA-78 in elderly patients with type 2 diabetes mellitus and deafness.Methods A total of 94 elderly patients with type 2 diabetes mellitus with deafness receiving treatment from July 2016 to July 2019 were randomly divided into observation group and control group by random number table method,47 cases each.All patients received hypoglycemc treatment and the basic treatment of improved cochlear microcirculation and nerve nutritional.Both groups were treated with batroxobin injection by intravenous driping 10 BU/time,once every 2 days,for 10 days.The observation group was additionally treated with vinpocetine by intravenous infusion,20 mg/time,once every 2 days,for 10 days.The total effective rate,fasting blood glucose and pure tone threshold at different time points before and after treatment,serum levels of visfatin and ENA-78 before and after treatment,high-cut viscosity of whole blood,low-cut viscosity of whole blood and plasma viscosity were compared.The correlation between pure tone threshold and serum levels of visfatin and ENA-78 was analyzed.Results The total effective rate of observation group was 89.36%,which was higher than 72.34%of the control group(P<0.05).The fasting blood glucose before treatment was comparable between the two groups(P>0.05).At different time points after treatment,the fasting blood glucose of the two groups was lower than that before treatment(P<0.05),but the difference between the two groups was not statistically significant(P>0.05),and no hypoglycemia events were observed during the treatment.At different time points after treatment,the pure tone hearing threshold of the two groups was lower than that before treatment(P<0.05).The pure tone thresholds of the observation group at 8 and 10 days after treatment were(52.60±3.11)dB,(48.42±2.02)dB,which were lower than those of the control group[(55.71±3.32)dB,(52.61±2.97)dB]with statistical significance(P<0.05).After 10 days of treatment,serum visfatin and ENA-78,whole blood high-cut viscosity,whole blood low-cut viscosity and plasma viscosity of the two groups were lower than those before treatment(P<0.05),and the decrease of the observation group was even larger(P<0.05).There was a significant positive correlation between pure tone threshold and serum visfatin(r=0.75,P<0.001),and a positive correlation with serum ENA-78(r=0.72,P<0.001).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Batroxobin combined with vinpocetine can play a synergistic role in the treatment of elderly type 2 diabetes with deafness,promoting the improvement of blood rheology and down-regulating serum visfatin,ENA-78,which promotes the recovery of hearing.Its effect is better than single batroxobin,and has higher security.