淀粉样蛋白A、C-反应蛋白与动脉硬化的相关性研究

目的研究淀粉样蛋白A、C-反应蛋白与动脉硬化的关系。方法收集2018年6月至2019年1月该院体检的人群749例,其中动脉硬化程度升高者360例,动脉硬化程度正常者389例,年龄18~84岁。评估体检人群的动脉硬化程度,检测并定量血清中淀粉样蛋白A。Logistic回归分析淀粉样蛋白A和C-反应蛋白与动脉硬化的关系。限制性3次样条分析进一步研究自变量与因变量的非线性关系。结果在未调整模型中,动脉硬化组中的C-反应蛋白和淀粉样蛋白A高于对照组(均P<0.05);充分调整协变量后两组间的C-反应蛋白水平差异相对变小(P=0.041),而两组间的淀粉样蛋白A水平差异仍然较大(P=0.003)。单因素Logistic回归发现C-反应蛋白和淀粉样蛋白A均与动脉硬化风险呈正相关,95%CI分别为3.299(1.575~6.910)、2.798(1.670~4.689)。多重Logistic回归发现未调整协变量的淀粉样蛋白A与动脉硬化风险呈正相关,95%CI为2.191(1.165~4.119),而C-反应蛋白与动脉硬化风险无关,这种趋势在充分调整协变量后仍然存在。限制性3次样条回归表明随着淀粉样蛋白A的升高,动脉硬化风险的变化呈现为类似于"指数"的增长模式。结论淀粉样蛋白A与动脉硬化存在正相关关系,而C-反应蛋白与动脉硬化的关系可能依赖于淀粉样蛋白A。

Correlation between amyloid A,C-reactive protein and arteriosclerosis

Objective To study the relationship between amyloid A and C-reactive protein and arteriosclerosis.Methods A total of 749 patients who underwent physical examination at the hospital from June 2018 to January 2019 were collected,including 360 cases with elevated arteriosclerosis and 389 patients with normal arteriosclerosis,aged 18 to 84 years old.Assess the degree of arteriosclerosis in the physical examination,detected and quantifed serum amyloid A.Logistic regression analysis of the relationship between amyloid A and C-reactive protein and arteriosclerosis.Restricted cubic spline analysis further investigates the nonlinear relationship between independent and dependent variables.Results In the unadjusted model,the C-reactive protein and amyloid A in the arteriosclerosis group were higher than those in the control group(all P<0.05);the C-reactive protein levels between the two groups were relatively changed after the covariates were fully adjusted small(P=0.041),while the difference in amyloid A levels between the two groups was still large(P=0.003).Univariate Logistic regression showed that C-reactive protein and amyloid A were positively correlated with the risk of arteriosclerosis,95%CI were 3.299(1.575-6.910)and 2.798(1.670-4.689),respectively.Multiple Logistic regression found that amyloid A with unadjusted covariates was positively correlated with the risk of arteriosclerosis,95%CI was 2.191(1.165-4.119),while C-reactive protein was not related to the risk of atherosclerosis,and this trend still existed after fully adjusting covariates.The results showed that with the increase of amyloid A,the risk of atherosclerosis showed an exponential growth pattern.Conclusion There is apositive correlation between amyloid A and atherosclerosis,while the relationship between C-reactive protein and atherosclerosis may depend on amyloid A.